Pharmacokinetic study of intravenously administered artemisinin-loaded surface-decorated amphiphilic γ-cyclodextrin nanoparticles.
Artemisinin
Bioesterified γ-cyclodextrins
Healthy rats
Intravenous administration
Pharmacokinetic parameters
Surface-decorated nanoparticles
Journal
Materials science & engineering. C, Materials for biological applications
ISSN: 1873-0191
Titre abrégé: Mater Sci Eng C Mater Biol Appl
Pays: Netherlands
ID NLM: 101484109
Informations de publication
Date de publication:
Jan 2020
Jan 2020
Historique:
received:
10
04
2019
revised:
11
09
2019
accepted:
05
10
2019
entrez:
23
11
2019
pubmed:
23
11
2019
medline:
2
4
2020
Statut:
ppublish
Résumé
Artemisinin and its derivatives are currently recommended by World Health Organization for the treatment of malaria. Severe malaria requires a parenteral administration of artemisinin-based formulations. However, the effective use of artemisinin is limited by the pharmacokinetic characteristics of the drug (low water solubility, poor bioavailability and short half-life). To overcome some of these drawbacks, artemisinin-loaded surface-decorated nanoparticles were prepared by co-nanoprecipitation of γ-cyclodextrin bioesterified with C
Identifiants
pubmed: 31753335
pii: S0928-4931(19)31347-5
doi: 10.1016/j.msec.2019.110281
pii:
doi:
Substances chimiques
Antimalarials
0
Artemisinins
0
Drug Carriers
0
gamma-Cyclodextrins
0
Polyethylene Glycols
3WJQ0SDW1A
gamma-cyclodextrin
KZJ0BYZ5VA
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
110281Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.