ITPK1 mediates the lipid-independent synthesis of inositol phosphates controlled by metabolism.
Amino Acid Sequence
Archaeal Proteins
/ metabolism
Conserved Sequence
HCT116 Cells
Humans
Hydrolysis
Inositol
/ metabolism
Inositol Phosphates
/ biosynthesis
Phosphorylation
Phosphotransferases (Alcohol Group Acceptor)
/ chemistry
Saccharomyces cerevisiae
/ metabolism
Sphingolipids
/ metabolism
Type C Phospholipases
/ metabolism
glucose
inositol phosphate
metabolism
phosphate
phospholipase C
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
03 12 2019
03 12 2019
Historique:
pubmed:
23
11
2019
medline:
14
4
2020
entrez:
23
11
2019
Statut:
ppublish
Résumé
Inositol phosphates (IPs) comprise a network of phosphorylated molecules that play multiple signaling roles in eukaryotes. IPs synthesis is believed to originate with IP
Identifiants
pubmed: 31754032
pii: 1911431116
doi: 10.1073/pnas.1911431116
pmc: PMC6900528
doi:
Substances chimiques
Archaeal Proteins
0
Inositol Phosphates
0
Sphingolipids
0
Inositol
4L6452S749
Phosphotransferases (Alcohol Group Acceptor)
EC 2.7.1.-
inositol-tetrakisphosphate 1-kinase
EC 2.7.1.-
ITPK1 protein, human
EC 2.7.1.134
Type C Phospholipases
EC 3.1.4.-
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
24551-24561Subventions
Organisme : Medical Research Council
ID : MC_UU_00012/4
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_12018/4
Pays : United Kingdom
Organisme : NIGMS NIH HHS
ID : R15 GM106322
Pays : United States
Organisme : Medical Research Council
ID : MC_UU12018/4
Pays : United Kingdom
Informations de copyright
Copyright © 2019 the Author(s). Published by PNAS.
Déclaration de conflit d'intérêts
The authors declare no competing interest.
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