Smart antimicrobial efficacy employing pH-sensitive ZnO-doped diamond-like carbon coatings.
Animals
Anti-Bacterial Agents
/ chemistry
Bacteria
/ drug effects
Bacterial Adhesion
/ drug effects
Carbon
/ chemistry
Cell Line
Coated Materials, Biocompatible
/ chemistry
Fibroblasts
/ drug effects
Hydrogen-Ion Concentration
Methicillin
/ pharmacology
Mice
Nanoparticles
/ chemistry
Oxacillin
/ pharmacology
Prostheses and Implants
Surface Properties
/ drug effects
Zinc Oxide
/ chemistry
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
21 11 2019
21 11 2019
Historique:
received:
28
08
2019
accepted:
31
10
2019
entrez:
23
11
2019
pubmed:
23
11
2019
medline:
6
11
2020
Statut:
epublish
Résumé
One of the main challenges in endoprosthesis surgeries are implant-associated infections and aseptic-loosenings, caused by wear debris. To combat these problems, the requirements to surfaces of endoprostheses are wear-resistance, low cytotoxicity and antimicrobial efficacy. We here present antimicrobial coatings with a smart, adaptive release of metal ions in case of infection, based on ZnO-nanoparticles embedded in diamond-like carbon (DLC). The Zn
Identifiants
pubmed: 31754198
doi: 10.1038/s41598-019-53521-7
pii: 10.1038/s41598-019-53521-7
pmc: PMC6872652
doi:
Substances chimiques
Anti-Bacterial Agents
0
Coated Materials, Biocompatible
0
Carbon
7440-44-0
Methicillin
Q91FH1328A
Zinc Oxide
SOI2LOH54Z
Oxacillin
UH95VD7V76
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
17246Références
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