Promoter Methylation of Four Tumor Suppressor Genes in Human Papillary Thyroid Carcinoma.
Methylation
Papillary thyroid cancers
Tumor suppressor genes
Journal
Iranian journal of pathology
ISSN: 1735-5303
Titre abrégé: Iran J Pathol
Pays: Iran
ID NLM: 101515128
Informations de publication
Date de publication:
2019
2019
Historique:
received:
25
09
2018
accepted:
27
07
2019
entrez:
23
11
2019
pubmed:
23
11
2019
medline:
23
11
2019
Statut:
ppublish
Résumé
Papillary thyroid cancer (PTC) is considered to be the most common type of thyroid malignancies. Epigenetic alteration, in which the chromatin conformation and gene expression change without changing the sequence of DNA, can occur in some tumor suppressor genes and oncogenes. Methylation is the most common type of epigenetic alterations that can be an excellent indicator of PTC invasive behavior. In this research, we determined the promoter methylation status of four tumor suppressor genes ( Our data showed that the promoter methylation of RASSF1 promoter methylation can be a PTC genetic marker. RASSF1 promoter methylation is under the impact of the methyltransferase genes (DNMT1 and MGMT), protein expression, and promoter methylation.
Sections du résumé
BACKGROUND & OBJECTIVE
OBJECTIVE
Papillary thyroid cancer (PTC) is considered to be the most common type of thyroid malignancies. Epigenetic alteration, in which the chromatin conformation and gene expression change without changing the sequence of DNA, can occur in some tumor suppressor genes and oncogenes. Methylation is the most common type of epigenetic alterations that can be an excellent indicator of PTC invasive behavior.
METHODS
METHODS
In this research, we determined the promoter methylation status of four tumor suppressor genes (
RESULTS
RESULTS
Our data showed that the promoter methylation of
CONCLUSION
CONCLUSIONS
RASSF1 promoter methylation can be a PTC genetic marker. RASSF1 promoter methylation is under the impact of the methyltransferase genes (DNMT1 and MGMT), protein expression, and promoter methylation.
Identifiants
pubmed: 31754358
doi: 10.30699/ijp.2019.94401.1922
pmc: PMC6824767
doi:
Types de publication
Journal Article
Langues
eng
Pagination
290-298Déclaration de conflit d'intérêts
The authors declared no conflict of interest regarding the publication of this article.
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