Implant materials and prosthetic joint infection: the battle with the biofilm.
biofilm
implant
material
microbiology
prosthetic joint infection
surface coating
Journal
EFORT open reviews
ISSN: 2058-5241
Titre abrégé: EFORT Open Rev
Pays: England
ID NLM: 101695674
Informations de publication
Date de publication:
Nov 2019
Nov 2019
Historique:
entrez:
23
11
2019
pubmed:
23
11
2019
medline:
23
11
2019
Statut:
epublish
Résumé
Prosthetic joint infection (PJI) is associated with poor clinical outcomes and is expensive to treat.Although uncommon overall (affecting between 0.5% and 2.2% of cases), PJI is one of the most commonly encountered complications of joint replacement and its incidence is increasing, putting a significant burden on healthcare systems.Once established, PJI is extremely difficult to eradicate as bacteria exist in biofilms which protect them from antibiotics and the host immune response.Improved understanding of the microbial pathology in PJI has generated potential new treatment strategies for prevention and eradication of biofilm associated infection including modification of implant surfaces to prevent adhesion of bacteria.Much research is currently ongoing looking at different implant surface coatings and modifications, and although most of this work has not translated into clinical medicine there has been some early clinical success. Cite this article:
Identifiants
pubmed: 31754470
doi: 10.1302/2058-5241.4.180095
pii: 10.1302_2058-5241.4.180095
pmc: PMC6851527
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
633-639Informations de copyright
© 2019 The author(s).
Déclaration de conflit d'intérêts
ICMJE Conflict of interest statement: DJD reports grants from Royal College of Surgeons Research Fellowship and grants from ORUK during the conduct of the study. ADL reports two unrestricted charitable grants from Orthopaedic Research UK, Royal College of Surgeons; expenses for travel to educational meetings for Stryker, Zimmer, Biomet, de Puy and Implantcast. DS reports no conflict of interest relevant to this work.
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