Trends in the Abscopal Effect After Radiation to Spinal Metastases: A Systematic Review.
abscopal
checkpoint inhibitors
immunomodulators
immunotherapy
metastasis
neurosurgery
radiation
spinal metastases
spine
Journal
Cureus
ISSN: 2168-8184
Titre abrégé: Cureus
Pays: United States
ID NLM: 101596737
Informations de publication
Date de publication:
05 Oct 2019
05 Oct 2019
Historique:
entrez:
23
11
2019
pubmed:
23
11
2019
medline:
23
11
2019
Statut:
epublish
Résumé
While the abscopal effect has been previously described, the phenomenon has been poorly defined in the case of spinal metastases. This article is unique in that we present the first systematic review of the abscopal effect after radiation therapy to metastatic spinal cancer, especially since the spinal column represents one of the most common metastatic locations. Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines in the Enhancing the QUAlity and Transparency Of health Research (EQUATOR) resources, a systematic review identified relevant studies via a computer-aided search of MEDLINE and Embase. Ten publications that met the inclusion and exclusion criteria from the PRISMA flow diagram described a total of 13 patients, 76.9% of whom demonstrated image findings of the abscopal effect. In summary, important trends in the nine patients who experienced the abscopal effect in this review include higher doses of radiation and treatment with immunomodulators, both of which may help guide treatment paradigms for spinal metastases superimposed on diffuse metastatic disease. These trends, however, still warrant further investigations with experimental and clinical studies for a mechanistic understanding of the abscopal effect.
Identifiants
pubmed: 31754579
doi: 10.7759/cureus.5844
pmc: PMC6830850
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
e5844Informations de copyright
Copyright © 2019, Macki et al.
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
Références
Oncoimmunology. 2014 May 14;3:e28780
pubmed: 25083318
JCO Precis Oncol. 2018 Nov;2:1-6
pubmed: 35135149
Radiology. 1963 Mar;80:471-6
pubmed: 13930395
Eur J Cancer. 2016 Nov;68:156-162
pubmed: 27764686
Curr Probl Cancer. 2016 Jan-Feb;40(1):10-24
pubmed: 26612692
J Clin Oncol. 2018 Jun 1;36(16):1611-1618
pubmed: 29437535
Nature. 2015 Apr 16;520(7547):373-7
pubmed: 25754329
N Engl J Med. 2011 Jun 30;364(26):2517-26
pubmed: 21639810
Nat Rev Cancer. 2015 Jul;15(7):409-25
pubmed: 26105538
Clin Radiol. 1981 Jul;32(4):475-80
pubmed: 7249526
Curr Probl Cancer. 2016 Jan-Feb;40(1):25-37
pubmed: 26582738
Gut. 1998 Oct;43(4):575-7
pubmed: 9824589
Radiat Oncol. 2009 Dec 31;4:71
pubmed: 20043839
PLoS Med. 2009 Jul 21;6(7):e1000097
pubmed: 19621072
Cancer. 1975 Jun;35(6):1621-5
pubmed: 1148995
Pract Radiat Oncol. 2017 Nov - Dec;7(6):396-399
pubmed: 28551390
N Engl J Med. 2010 Aug 19;363(8):711-23
pubmed: 20525992
Cancer Biol Ther. 2018 Jan 2;19(1):20-24
pubmed: 29281479
Br J Radiol. 1953 May;26(305):234-41
pubmed: 13042090
Mol Clin Oncol. 2018 Sep;9(3):283-286
pubmed: 30155251
Cancer Res. 2007 Apr 15;67(8):3845-52
pubmed: 17440099
Nat Rev Cancer. 2018 May;18(5):313-322
pubmed: 29449659
Spine (Phila Pa 1976). 2017 Jun 15;42(12):E721-E725
pubmed: 27879568
Clin Cancer Res. 2009 Sep 1;15(17):5379-88
pubmed: 19706802
Clin Genitourin Cancer. 2012 Sep;10(3):196-8
pubmed: 22409865
J Immunother. 2016 Nov/Dec;39(9):367-372
pubmed: 27741091
N Engl J Med. 2012 Mar 8;366(10):925-31
pubmed: 22397654
Cancer Lett. 2015 Jan 1;356(1):82-90
pubmed: 24125863
J Natl Cancer Inst. 1979 Nov;63(5):1229-35
pubmed: 291749
Oncoimmunology. 2017 Nov 27;7(3):e1395996
pubmed: 29399393