Incidence and Clearance of Anal Human Papillomavirus (HPV)-16 and HPV-18 Infection, and Their Determinants, Among Human Immunodeficiency Virus-Infected Men Who Have Sex With Men in France.
Anus Diseases
/ epidemiology
France
/ epidemiology
HIV Infections
/ complications
Homosexuality, Male
Human papillomavirus 16
Human papillomavirus 18
Humans
Incidence
Male
Middle Aged
Papillomavirus Infections
/ complications
Prospective Studies
Risk Factors
Sexual Behavior
Sexual and Gender Minorities
anal HPV infection
human immunodeficiency virus
incidence
men who have sex with men
Journal
The Journal of infectious diseases
ISSN: 1537-6613
Titre abrégé: J Infect Dis
Pays: United States
ID NLM: 0413675
Informations de publication
Date de publication:
07 04 2020
07 04 2020
Historique:
received:
26
09
2019
accepted:
21
11
2019
pubmed:
23
11
2019
medline:
5
2
2021
entrez:
23
11
2019
Statut:
ppublish
Résumé
Prospective data on the natural history of anal human papillomavirus (HPV) infection are scarce in human immunodeficiency virus (HIV)-infected men who have sex with men (MSM). We analyzed incidence and clearance of HPV-16 and HPV-18 in a French cohort of HIV-infected MSM, aged ≥35 years, followed-up annually (n = 438, 2014-2018). Human papillomavirus-16 and HPV-18 incidence were similar (~10% incident infections at 24 months). Human papillomavirus-16 incidence was higher among high-grade versus no lesion at baseline (adjusted incidence rate ratio = 3.0; 95% confidence interval, 1.07-8.18). Human papillomavirus-16 cleared significantly slower than HPV-18 (32% versus 54% by 24 months). In conclusion, anal HPV-16 is more persistent than HPV-18, and its incidence correlates with a prior detection of high-grade lesions.
Sections du résumé
BACKGROUND
Prospective data on the natural history of anal human papillomavirus (HPV) infection are scarce in human immunodeficiency virus (HIV)-infected men who have sex with men (MSM).
METHODS
We analyzed incidence and clearance of HPV-16 and HPV-18 in a French cohort of HIV-infected MSM, aged ≥35 years, followed-up annually (n = 438, 2014-2018).
RESULTS
Human papillomavirus-16 and HPV-18 incidence were similar (~10% incident infections at 24 months). Human papillomavirus-16 incidence was higher among high-grade versus no lesion at baseline (adjusted incidence rate ratio = 3.0; 95% confidence interval, 1.07-8.18). Human papillomavirus-16 cleared significantly slower than HPV-18 (32% versus 54% by 24 months).
CONCLUSIONS
In conclusion, anal HPV-16 is more persistent than HPV-18, and its incidence correlates with a prior detection of high-grade lesions.
Identifiants
pubmed: 31754686
pii: 5637552
doi: 10.1093/infdis/jiz623
doi:
Types de publication
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1488-1493Investigateurs
C Arvieux
(C)
A Canestri
(A)
G M Clifford
(GM)
J D Combes
(JD)
V Costes-Martineau
(V)
J Del Grande
(J)
J M Didelot
(JM)
I Etienney
(I)
M Falguières
(M)
T Ferry
(T)
H Fischer
(H)
J F Flejou
(JF)
I Heard
(I)
S Henno
(S)
N Hoyau
(N)
M Landon
(M)
H Laude
(H)
F Le Breton
(F)
A C Lesage
(AC)
A Lion
(A)
G Maincent
(G)
L Marchand
(L)
H Njatonirina
(H)
O Patey
(O)
V Petrov Sanchez
(V)
V Pialoux
(V)
L Piroth
(L)
I Poizot-Martin
(I)
O Zaegel-Faucher
(O)
E Ressiot
(E)
S Radenne
(S)
J Reynes
(J)
L Siproudhis
(L)
C Tamalet
(C)
P Tattevin
(P)
Informations de copyright
© The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.