Relevance of preclinical rodent pharmacokinetics in the selection of a companion antibiotic for combining with beta-lactamase inhibitor.

Animals Azabicyclo Compounds / metabolism Ceftazidime / metabolism Cyclooctanes Drug Combinations Mice Microbial Sensitivity Tests Piperidines Rats Rodentia beta-Lactamase Inhibitors / metabolism
Beta-lactamase inhibitor cephalosporins/penems clinical development pairing the antibiotic pharmacokinetics preclinical

Journal

Xenobiotica; the fate of foreign compounds in biological systems
ISSN: 1366-5928
Titre abrégé: Xenobiotica
Pays: England
ID NLM: 1306665

Informations de publication

Date de publication:
Jul 2020
Historique:
pubmed: 23 11 2019
medline: 22 7 2020
entrez: 23 11 2019
Statut: ppublish

Résumé

Recent approvals of beta-lactamase inhibitor (BLI) drug in combination with cephalosporins/penems have provided the right impetus for novel BLIs. One important research question, hitherto not addressed, is pertaining to the relevance of preclinical pharmacokinetics for pairing the antibiotic with existing/novel BLI.Two BLI combination drugs: (a) approved (i.e. ceftazidime/avibactam); (b) clinical development (i.e. cefepime/zidebactam) were explored to provide insights to address the research question.Individual intravenous dosing of ceftazidime, avibactam, cefepime and zidebactam was done at 1 mg/kg by intravenous route in Balb/c mice and Wistar rats. Serial blood samples were collected and analysed by LC-MS/MS method.Examination of the ratios of pharmacokinetic parameters (CL,

Identifiants

DOI: 10.1080/00498254.2019.1696494 PMID: 31755347
pubmed: 31755347
doi: 10.1080/00498254.2019.1696494
doi:

Substances chimiques

Azabicyclo Compounds 0
Cyclooctanes 0
Drug Combinations 0
Piperidines 0
avibactam, ceftazidime drug combination 0
beta-Lactamase Inhibitors 0
zidebactam 0
avibactam 7352665165
Ceftazidime 9M416Z9QNR

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

815-821

Auteurs

Poonam Giri (P)

Department of Drug Metabolism and Pharmacokinetics, Zydus Research Centre, Ahmadabad, India.

Prashant Delvadia (P)

Department of Drug Metabolism and Pharmacokinetics, Zydus Research Centre, Ahmadabad, India.

Meera K Ladani (MK)

Department of Drug Metabolism and Pharmacokinetics, Zydus Research Centre, Ahmadabad, India.

Namrata Prajapati (N)

Department of Drug Metabolism and Pharmacokinetics, Zydus Research Centre, Ahmadabad, India.

Vipul Joshi (V)

Department of Drug Metabolism and Pharmacokinetics, Zydus Research Centre, Ahmadabad, India.

Shyamkumar Giri (S)

Department of Drug Metabolism and Pharmacokinetics, Zydus Research Centre, Ahmadabad, India.

Nirmal Patel (N)

Department of Drug Metabolism and Pharmacokinetics, Zydus Research Centre, Ahmadabad, India.

Mukul R Jain (MR)

Department of Drug Metabolism and Pharmacokinetics, Zydus Research Centre, Ahmadabad, India.
Department of Pharmacology and Toxicology, Zydus Research Centre, Ahmadabad, India.

Nuggehally R Srinivas (NR)

Department of Drug Metabolism and Pharmacokinetics, Zydus Research Centre, Ahmadabad, India.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Relevance of preclinical rodent...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques, cycle ponté › Composés hétérocycliques bicycliques › Composés azabicycliques › Relevance of preclinical rodent...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › bêta-Lactames › Céphalosporines › Céfaloridine › Ceftazidime › Relevance of preclinical rodent...
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questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Relevance of preclinical rodent...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antibactériens › Inhibiteurs des bêta-lactamases › Relevance of preclinical rodent...