Associations between maternal depression and mother and infant oxytocin receptor gene (OXTR_rs53576) polymorphisms.
infant temperament
mood disorders
oxytocin receptor gene
postpartum depression
Journal
Developmental psychobiology
ISSN: 1098-2302
Titre abrégé: Dev Psychobiol
Pays: United States
ID NLM: 0164074
Informations de publication
Date de publication:
05 2020
05 2020
Historique:
received:
29
05
2019
revised:
02
10
2019
accepted:
20
10
2019
pubmed:
23
11
2019
medline:
29
6
2021
entrez:
23
11
2019
Statut:
ppublish
Résumé
Polymorphisms in the oxytocin receptor gene, OXTR_rs53576, have been linked to differences in maternal sensitivity and depressive symptoms. Although some studies suggest the A allele confers risk for mood disorders, individuals homozygous for the G allele may exhibit greater sensitivity to both positive and negative social experiences, including in the mother-infant dyad. Given the bi-directional nature of mother-infant influences on maternal mood, we tested the association between both mothers' and infants' OXTR_rs53576 genotype and maternal depression, as assessed through a self-report inventory. Although Beck Depression Inventory (BDI-II) scores were significantly higher for GG in comparison to AG/AA mothers, and for mothers of GG in comparison to AG/AA infants, an ANCOVA revealed that after sociodemographic risk factors had been controlled, infants', but not mothers', OXTR genotype predicted maternal depression scores, with no significant interaction between the two. The effect of infant OXTR on maternal depression was not explained by maternal reports of difficult infant temperament. We propose that GG infants have an enhanced capacity for processing both positive and negative socially meaningful contextual information, first amplifying and then differentially perpetuating negative affectivity in mothers who exhibit depressive characteristics.
Substances chimiques
OXTR protein, human
0
Receptors, Oxytocin
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
496-504Subventions
Organisme : ORS NIH HHS
Pays : United States
Organisme : the College of Liberal Arts & Sciences
Pays : International
Organisme : ORS NIH HHS
Pays : United States
Informations de copyright
© 2019 Wiley Periodicals, Inc.
Références
Apter-Levy, Y., Feldman, M., Vakart, A., Ebstein, R. P., & Feldman, R. (2013). Impact of maternal depression across the first 6 years of life on the child’s mental health, social engagement, and empathy: The moderating role of oxytocin. American Journal of Psychiatry, 170, 1161-1168. https://doi.org/10.1176/appi.ajp.2013.12121597
Augustine, M. E., Leerkes, E. M., Smolen, A., & Calkins, S. D. (2017). Relations between early maternal sensitivity and toddler self-regulation: Exploring variation by oxytocin and dopamine D2 receptor genes. Developmental Psychobiology, 60, 789-804. https://doi.org/10.1002/dev.21745
Bakermans-Kranenburg, M. J., & Van Ijzendoorn, M. H. (2008). Oxytocin receptor (OXTR) and serotonin transporter (5-HTT) genes associated with observed parenting. Social Cognitive and Affective Neuroscience, 3(2), 128-134. https://doi.org/10.1093/scan/nsn004
Bakermans-Kranenburg, M. J., & Van Ijzendoorn, M. H. (2014). A sociability gene? Meta-analysis of oxytocin receptor genotype effects in humans. Psychiatric Genetics, 24, 45-51. https://doi.org/10.1037/0033-2909.129.2.195
Baron, R. M., & Kenny, K. A. (1986). The moderator-mediator variable distinction in social psychological research: Conceptual, strategic, and statistical considerations. Journal of Personality and Social Psychology, 51, 1173-1182. https://doi.org/10.1037/0022-3514.51.6.1173
Bates, J. E., Freeland, C. A., & Lounsbury, M. L. (1979). Measurement of infant difficultness. Child Development, 50(3), 794-803. https://doi.org/10.2307/1128946
Beck, A. T., Steer, R., & Brown, G. (1996). Manual for the Beck Depression Inventory-II. San Antonio, TX: Psychological Corporation.
Beck, C. T., & Gable, R. K. (2000). Postpartum depression screening scale: Development and psychometric testing. Nursing Research, 49, 272-282. https://doi.org/10.1097/00006199-200009000-00006
Bell, A. F., Carter, C. S., Steer, C. D., Golding, J., Davis, J. M., Steffen, A. D., … Connelly, J. J. (2015). Interaction between oxytocin receptor DNA methylation and genotype is associated with risk of postpartum depression in women without depression in pregnancy. Frontiers in Genetics, 6, 243. https://doi.org/10.3389/fgene.2015.00243
Belsky, J., & Pluess, M. (2009). The nature (and nurture?) of plasticity in early human development. Perspectives on Psychological Science, 4, 345-351. https://doi.org/10.1111/j.1745-6924.2009.01136.x
Burkhouse, K. L., Woody, M. L., Owens, M., McGeary, J. E., Knopik, V. & Gibb, B. E. (2016). Sensitivity in detecting facial displays of emotion: Impact of maternal depression and oxytocin receptor type. Cognition and Emotion, 30, 275-287. 1080/02699931.2014.996531
Button, K. S., Ioannidis, J. P., Mokrysz, C., Nosek, B. A., Flint, J., Robinson, E. S., & Munafò, M. R. (2013). Power failure: Why small sample size undermines the reliability of neuroscience. Nature Reviews Neuroscience, 14, 365-376. https://doi.org/10.1038/nm3475
Chen, F. S., Kumsta, R., von Dawans, B., Monakhov, M., Ebstein, R. P., & Heinrichs, M. (2011). Common oxytocin receptor gene (OXTR) polymorphism and social support interact to reduce stress in humans. Proceeding of the National Academy of Sciences, 108, 19937-19942. https://doi.org/10.1073/pnas.1113079108
Choi, D., Tsuchiya, K., & J., & Nori, T., (2019). Interaction effect of oxytocin receptor (OXTR) rs53576 genotype and maternal postpartum depression on child behavioural problems. Scientific Reports, 9, 1-8. https://doi.org/10.1038/s41598-019-44175-6
Costa, B., Pini, S., Gabelloni, P., Abelli, M., Lari, L., Cardini, A., … Martini, C. (2009). Oxytocin receptor polymorphisms and adult attachment style in patients with depression. Psychoneuroendocrinology, 34(10), 1506-1514. https://doi.org/10.1016/j.psyneuen.2009.05.006
Cox, J. L., Holden, J. M., & Sagovsky, R. (1987). Detection of postnatal depression. Development of the 10-item Edinburgh postnatal depression scale. British Journal ofPsychiatry, 150, 782-786. https://doi.org/10.1192/bjp.150.6.782
Feldman, R. (2012). Parent-infant synchrony: A biobehavioral model of mutual influences in the formation of affiliative bonds. Monographs of the Society for Research in Child Development, 77, 42-51. https://doi.org/10.1111/j.1540-5834.2011.00660.x
Feldman, R., Weller, A., Zagoory-Sharon, O., & Levine, A. (2007). Evidence for a neuroendocrinological foundation of human affiliation: Plasma oxytocin levels across pregnancy and the postpartum period predict mother-infant bonding. Psychological Sciences, 18, 965-970. https://doi.org/10.1111/j.1467-9280.2007.02010.x
Glynn, L. M., Howland, M. A., & Fox, M. (2018). Maternal programming: Application of a developmental psychopathology perspective. Development & Psychopathology, 30, 905-919. https://doi.org/10.1017/S095545794180000524
Goodman, S. H., & Gotlib, I. H. (1999). Risk for psychopathology in the children of depressed mothers: A developmental model for understanding mechanisms of transmission. Psychological Review, 106, 458-490. https://doi.org/10.1037/0033-295X.106.3.458
Kim, H. S., Sherman, D. K., Sasaki, J. Y., Xu, J., Chu, T. Q., Ryu, C., … Taylor, S. E. (2010). Culture, distress, and oxytocin receptor polymorphism (OXTR) interact to influence emotional support seeking. Proceedings of the National Academy of Sciences of the United States of America, 107(36), 15717-15721. https://doi.org/10.1073/pnas.1010830107
Kimmel, M., Clive, M., Gispen, F., Guintivano, J., Brown, T., Cox, O., … Kaminsky, Z. (2016). Oxytocin receptor DNA methylation in postpartum depression. Psychoneuroendocrinology, 69, 150-160. https://doi.org/10.1016/j.psyneuen.2016.04.008
Klahr, A. M., Klump, K. L., & Burt, S. A. (2015). A constructive replication of the association between the oxytocin receptor genotype and parenting. Journal of Family Psychology, 29, 91-99. https://doi.org/10.1037/fam0000034.
Krueger, F., Parasuraman, R., Ivengar, V., Thornburg, M., Weel, J., Lin, M., … Lipsyky, R. (2012). Oxytocin receptor genetic variation promotes human trust behavior. Frontiers in Human Neuroscience, 6, 1-9. https://doi.org/10.3389/fnhum.2012.00004
Kryski, K. R., Smith, H. J., Sheikh, H. I., Singh, S. M., & Hayden, E. P. (2014). Evidence for evocative gene-environment correlation between child oxytocin receptor (OXTR) genotype and caregiver behavior. Personality and Individual Differences, 64, 107-110. https://doi.org/10.1016/j.paid.2014.02.028
Kushner, S. C., Herzhoff, K., Vrshek-Schallhorn, S., & Tackett, J. (2018). Depression in early adolescence: Contributions from relational aggression and variation in the oxytocin receptor gene. Aggressive Behavior, 44, 60-68. https://doi.org/10.1002/ab.21724
Li, J., Zhao, Y., Li, R., Broster, L. S., Zhou, C., & Yang, S. (2017). Association of oxytocin receptor gene (OXTR) rs 53576 polymorphism with sociality: A meta-analysis. PLoS ONE, 10(6), e0131820. https://doi.org/10.1371/journal.pone.013820
Liu, J. H. (2013). Endocrinology of pregnancy. In C. J. Lockwood, J. D. Iams, & M. F. Greene (Eds.), Creasy and Resnik’s maternal-fetal medicine: Principles and practice. Elsevier Health Sciences: Philadelphia, PA.
Ludmer, J. A., Gonzalez, A., Kennedy, J., Masellis, M., Meinz, P., & Atkinson, L. (2018). Association between maternal childhood maltreatment and mother-infant attachment disorganization: Moderation by maternal oxytocin receptor gene. Hormones & Behavior, 102, 23-33. https://doi.org/10.1016/j.yhbeh.2018.04.006.
Luo, S., & Han, S. (2014). The association between an oxytocin receptor gene polymorphism and cultural orientations. Culture & Brain, 2, 89-107. https://doi.org/10.1007/s40167-014-0017-5
McQuaid, R. J., McInnis, O. A., Abizaid, A., & Anisman, H. (2014). Making room for oxytocin in understanding depression. Neuroscience and Biobehavioral Reviews, 45, 305-322. https://doi.org/10.1016/j.neubiorev.2014.07.005
McQuaid, R. J., McInnis, O. A., Matheson, K., & Anisman, H. (2015). Distress of ostracism: Oxytocin receptor gene polymorphism confers sensitivity to social exclusion. Social Cognitive and Affective Neuroscience, 10, 1153-1159. https://doi.org/10.1093/scan/nsu166
McQuaid, R. J., McInnis, O. A., Stead, J. D., Matheson, K., & Anisman, H. (2013). A paradoxical association of an oxytocin receptor gene polymorphism: Early-life adversity and vulnerability to depression. Frontiers in Neuroscience, 7, 128. https://doi.org/10.3389/fnins.2013.00128
Michalska, K. J., Deceti, J., Liu, C., Chen, Q., Martz, M. E., Jacob, S., … Lahey, B. B.. (2014). Genetic imaging of the association of oxytocin receptor (OXTR) polymorphisms with positive maternal parenting. Frontiers in Behavioral Neuroscience, 8, 1-10. https://doi.org/10.3389/fnbeh.2014.00021
Murray, L., & Cooper, P. J. (1997). Postpartum depression and child development. New York: Guilford.
Reiner, I., van IJzendoorn, M. H., Bakermans-Kranenburg, M. J., Bleich, S., and Beutel, M. (2015).Methylation of the oxytocin receptor gene in clinically depressed patients compared to controls. Journal of Psychiatric Research, 65, 9-15. https://doi.org/10.106/j.psychires.2015.03.1012
Riem, M. M., Pieper, S., Out, D., Bakermans-Kranenburg, M. J., & van IJzendoorn, M. H. (2011). Oxytocin receptor gene and depressive symptoms associated with physiological reactivity to infant crying. Social Cognitive and Affective Neuroscience, 6, 294-300. https://doi.org/10.1093/scan/nsq035
Roisman, G. I., Booth-Laforce, C., Belsky, J., Burt, K. B., & Groh, A. M. (2013). Molecular- genetic correlates of infant attachment: A cautionary tale. Attachment and Human Development, 15, 384-406. https://doi.org/10.1080/14616734.2013.768790
Saphire-Bernstein, S., Way, B. M., Kim, H. S., Sharman, D. K., & Taylor, S. E. (2011). Oxytocin receptor gene (OXTR) is related to psychological resources. Proceedings of the National Academy of Sciences, 108, 15118-15122. https://doi.org/10.1073/pnas.1113137108
Shamay-Tsoory, S. G., & Abu-Akel, A. (2016). The social salience hypothesis of oxytocin. Biological Psychiatry, 79, 194-202. https://doi.org/10.1016/j.biopsych.2015.07.020
Sharpley, C. F., & Rogers, H. J. (1984). Preliminary validation of the Abbreviated Spanier Dyadic Adjustment Scale: Some psychometric data regarding a screening test of marital adjustment. Educational and Psychological Measurement, 44, 1045-1049. https://doi-org.aurarialibrary.idm.oclc.org/10.1177/0013164484444029
Smearman, E. L., Winiarski, A., Brennan, P. A., Najman, J., & Johnson, K. C. (2015). Social stress and the oxytocin receptor gene interact to predict antisocial behavior in an at-risk cohort. Developmental Psychopathology, 27, 309-318. https://doi.org/10.1017/S0954579414000649
Smearman, E. L., Yu, T., & Brody, G. H. (2016). Variation in the oxytocin receptor gene moderates the protective effects of a family-based prevention program on telomere length. Brain & Behavior, 6, 1-12. https://doi.org/10.1002/brb3.423
Spanier, G. B. (1976). Measuring dyadic adjustment: New scales for assessing the quality of marriage and similar dyads. Journal of Marriage and the Family, 38, 15-25. https://doi.org/10.2307/350547
Sturge-Apple, M. L., Cicchetti, D., Davies, P. T., & Suor, J. H. (2012). Differential susceptibility in spillover between interparental conflict and maternal parenting practices: Evidence for OXTR and 5-HTT genes. Journal of Family Psychology, 26, 431. https://doi.org/10.1037/a0028302
Thompson, S. M., Hammen, C., Starr, L. R., & Najman, J. M. (2014). Oxytocin receptor gene polymorphism (rs53576) moderates the intergenerational transmission of depression Psychoneuroendocrinology, 43, 11-19. https://doi.org/10.1016/j.psyneuen.2014.01.012
Torkamani, A., Wineinger, N. E., & Topol, E. J. (2018). The personal and clinical utility of polygenic risk scores. Nature Reviews Genetics, 19, 581-590. https://doi.org/10.1038/s41576-018-0018-x
Tost, H., Kolachana, B., Hakimi, S., Lemaitre, H., Verchinski, B. A., Mattay, V. S., … Meyer-Lindenberg, A. (2010). A common allele in the oxytocin receptor gene (OXTR) impacts prosocial temperament and human hypothalamic-limbic structure and function. Proceedings of the National Academy of Sciences, 107, 13936-13941. https://doi.org/10.1073/pnas.1003296107
Wasilewska, K., Pawlak, A., Kostrzewa, G., Sobczyk-Kopciol, A., Kaczorowksa, A., Badowski, J., … Bielecki, W. (2017). OXTR polymorphism in depression and completed suicide: A study on a large population sample. Psychoneuroimmunology, 77, 84-89. https://doi.org/10.1016/j.psyneuen.2016.1