Differential effects of glucose deprivation on the survival of fetal versus adult neural stem cells-derived oligodendrocyte precursor cells.
Adult Stem Cells
/ drug effects
Animals
Cell Differentiation
/ drug effects
Cell Hypoxia
/ physiology
Cell Survival
/ drug effects
Cytokines
/ pharmacology
Glucose
/ metabolism
Inflammation
/ metabolism
Mice
Neural Stem Cells
/ drug effects
Oligodendrocyte Precursor Cells
/ drug effects
Oxygen
/ metabolism
hypoxia/ischemia
inflammation
oligodendrocyte precursor cells
oxygen-glucose deprivation
white matter lesion
Journal
Glia
ISSN: 1098-1136
Titre abrégé: Glia
Pays: United States
ID NLM: 8806785
Informations de publication
Date de publication:
05 2020
05 2020
Historique:
received:
08
08
2019
revised:
28
10
2019
accepted:
29
10
2019
pubmed:
23
11
2019
medline:
11
6
2021
entrez:
23
11
2019
Statut:
ppublish
Résumé
Impaired myelination is a key feature in neonatal hypoxia/ischemia (HI), the most common perinatal/neonatal cause of death and permanent disabilities, which is triggered by the establishment of an inflammatory and hypoxic environment during the most critical period of myelin development. This process is dependent on oligodendrocyte precursor cells (OPCs) and their capability to differentiate into mature oligodendrocytes. In this study, we investigated the vulnerability of fetal and adult OPCs derived from neural stem cells (NSCs) to inflammatory and HI insults. The resulting OPCs/astrocytes cultures were exposed to cytokines to mimic inflammation, or to oxygen-glucose deprivation (OGD) to mimic an HI condition. The differentiation of both fetal and adult OPCs is completely abolished following exposure to inflammatory cytokines, while only fetal-derived OPCs degenerate when exposed to OGD. We then investigated possible mechanisms involved in OGD-mediated toxicity: (a) T3-mediated maturation induction; (b) glutamate excitotoxicity; (c) glucose metabolism. We found that while no substantial differences were observed in T3 intracellular content regulation and glutamate-mediated toxicity, glucose deprivation lead to selective OPC cell death and impaired differentiation in fetal cultures only. These results indicate that the biological response of OPCs to inflammation and demyelination is different in fetal and adult cells, and that the glucose metabolism perturbation in fetal central nervous system (CNS) may significantly contribute to neonatal pathologies. An understanding of the underlying molecular mechanism will contribute greatly to differentiating myelination enhancing and neuroprotective therapies for neonatal and adult CNS white matter lesions.
Substances chimiques
Cytokines
0
Glucose
IY9XDZ35W2
Oxygen
S88TT14065
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
898-917Informations de copyright
© 2019 Wiley Periodicals, Inc.
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