Functional polymeric nerve guidance conduits and drug delivery strategies for peripheral nerve repair and regeneration.
Biomaterials
Drug delivery
Nerve guidance conduits
Neural tissue engineering
Peripheral nerve injury
Journal
Journal of controlled release : official journal of the Controlled Release Society
ISSN: 1873-4995
Titre abrégé: J Control Release
Pays: Netherlands
ID NLM: 8607908
Informations de publication
Date de publication:
10 01 2020
10 01 2020
Historique:
received:
02
10
2019
revised:
16
10
2019
accepted:
18
11
2019
pubmed:
23
11
2019
medline:
22
6
2021
entrez:
23
11
2019
Statut:
ppublish
Résumé
Peripheral nerve injuries can be extremely debilitating, resulting in sensory and motor loss-of-function. Endogenous repair is limited to non-severe injuries in which transection of nerves necessitates surgical intervention. Traditional treatment approaches include the use of biological grafts and alternative engineering approaches have made progress. The current article serves as a comprehensive, in-depth perspective on peripheral nerve regeneration, particularly nerve guidance conduits and drug delivery strategies. A detailed background of peripheral nerve injury and repair pathology, and an in-depth look into augmented nerve regeneration, nerve guidance conduits, and drug delivery strategies provide a state-of-the-art perspective on the field.
Identifiants
pubmed: 31756394
pii: S0168-3659(19)30671-6
doi: 10.1016/j.jconrel.2019.11.021
pii:
doi:
Substances chimiques
Biocompatible Materials
0
Pharmaceutical Preparations
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
78-95Subventions
Organisme : NIBIB NIH HHS
ID : R01 EB020640
Pays : United States
Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors have none to declare.