Marek's Disease Virus Infection of Natural Killer Cells.
CD107
CVI988
NK cells
RB-1B
cell tropism
chickens
interferon gamma (IFNγ)
meq
Journal
Microorganisms
ISSN: 2076-2607
Titre abrégé: Microorganisms
Pays: Switzerland
ID NLM: 101625893
Informations de publication
Date de publication:
20 Nov 2019
20 Nov 2019
Historique:
received:
16
10
2019
revised:
14
11
2019
accepted:
16
11
2019
entrez:
24
11
2019
pubmed:
24
11
2019
medline:
24
11
2019
Statut:
epublish
Résumé
Natural killer (NK) cells are key players in the innate immune response. They kill virus-infected cells and are crucial for the induction of adaptive immune responses. Marek's disease virus (MDV) is a highly contagious alphaherpesvirus that causes deadly T cell lymphomas in chickens. Host resistance to MDV is associated with differences in NK cell responses; however, the exact role of NK cells in the control of MDV remains unknown. In this study, we assessed if MDV can infect NK cells and alter their activation. Surprisingly, we could demonstrate that primary chicken NK cells are very efficiently infected with very virulent RB-1B MDV and the live-attenuated CVI988 vaccine. Flow cytometry analysis revealed that both RB-1B and CVI988 enhance NK cell degranulation and increase interferon gamma (IFNγ) production in vitro. In addition, we could show that the MDV Eco Q-encoded oncogene (
Identifiants
pubmed: 31757008
pii: microorganisms7120588
doi: 10.3390/microorganisms7120588
pmc: PMC6956363
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Volkswagen Foundation
ID : A112662
Organisme : Animal Health and Welfare ERA-Net
ID : MADISUP
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
Références
J Virol. 2000 Dec;74(23):11088-98
pubmed: 11070004
Avian Pathol. 1996 Jun;25(2):255-67
pubmed: 18645857
Dev Comp Immunol. 2010 Jul;34(7):759-67
pubmed: 20188123
Avian Dis. 1981 Oct-Dec;25(4):882-93
pubmed: 6279075
Nat Rev Microbiol. 2006 Apr;4(4):283-94
pubmed: 16541136
Virology. 2017 Mar;503:103-113
pubmed: 28160668
Curr Top Microbiol Immunol. 2001;255:91-120
pubmed: 11217429
J Gen Virol. 2017 May;98(5):1080-1088
pubmed: 28548038
Curr Top Microbiol Immunol. 2001;255:223-43
pubmed: 11217424
J Gen Virol. 2003 Oct;84(Pt 10):2635-45
pubmed: 13679597
Viruses. 2019 Mar 16;11(3):
pubmed: 30884829
Ann Rech Vet. 1988;19(3):193-201
pubmed: 3190140
Front Immunol. 2019 Apr 03;10:656
pubmed: 31024531
Avian Pathol. 2019 Apr;48(2):121-134
pubmed: 30556415
Dev Comp Immunol. 2008;32(11):1398-404
pubmed: 18579202
Nat Rev Immunol. 2015 Jun;15(6):388-400
pubmed: 25998963
Front Genet. 2018 Oct 09;9:456
pubmed: 30356667
Viral Immunol. 2009 Dec;22(6):431-44
pubmed: 19951180
J Leukoc Biol. 2004 Feb;75(2):163-89
pubmed: 14525967
J Virol. 2008 Nov;82(21):10820-31
pubmed: 18715907
Sci Rep. 2013;3:2478
pubmed: 23963354
Proc Natl Acad Sci U S A. 2015 Jun 9;112(23):7279-84
pubmed: 26039998
Avian Pathol. 1987;16(1):51-60
pubmed: 18766591
mSphere. 2019 Oct 9;4(5):
pubmed: 31597721
Dev Comp Immunol. 2013 Nov;41(3):439-46
pubmed: 23588041
Proc Natl Acad Sci U S A. 2018 Nov 6;115(45):11603-11607
pubmed: 30337483
Nat Rev Immunol. 2007 Apr;7(4):279-91
pubmed: 17380157
Annu Rev Immunol. 2013;31:163-94
pubmed: 23298212
Trends Immunol. 2004 Jan;25(1):47-52
pubmed: 14698284
Proc Natl Acad Sci U S A. 2004 Aug 10;101(32):11815-20
pubmed: 15289599
J Virol. 2012 Aug;86(16):8536-45
pubmed: 22647701
Eur J Immunol. 1994 Jul;24(7):1685-91
pubmed: 8026528
J Immunol. 2006 Feb 1;176(3):1517-24
pubmed: 16424180
J Virol. 2003 Aug;77(16):8712-8
pubmed: 12885890
Vet Immunol Immunopathol. 2003 Oct 15;95(3-4):145-53
pubmed: 12963275