Insights into the Regulation of Tumor Angiogenesis by Micro-RNAs.
anti-angiogenic therapies
endothelial cells
microRNAs
tumor angiogenesis
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
20 Nov 2019
20 Nov 2019
Historique:
received:
07
10
2019
revised:
07
11
2019
accepted:
14
11
2019
entrez:
24
11
2019
pubmed:
24
11
2019
medline:
24
11
2019
Statut:
epublish
Résumé
One of the hallmarks of cancer is angiogenesis, a series of events leading to the formation of the abnormal vascular network required for tumor growth, development, progression, and metastasis. MicroRNAs (miRNAs) are short, single-stranded, non-coding RNAs whose functions include modulation of the expression of pro- and anti-angiogenic factors and regulation of the function of vascular endothelial cells. Vascular-associated microRNAs can be either pro- or anti-angiogenic. In cancer, miRNA expression levels are deregulated and typically vary during tumor progression. Experimental data indicate that the tumor phenotype can be modified by targeting miRNA expression. Based on these observations, miRNAs may be promising targets for the development of novel anti-angiogenic therapies. This review discusses the role of various miRNAs and their targets in tumor angiogenesis, describes the strategies and challenges of miRNA-based anti-angiogenic therapies and explores the potential use of miRNAs as biomarkers for anti-angiogenic therapy response.
Identifiants
pubmed: 31757094
pii: jcm8122030
doi: 10.3390/jcm8122030
pmc: PMC6947031
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Associazione Italiana per la Ricerca sul Cancro
ID : 20441 to V.R.
Références
Tumour Biol. 2017 Apr;39(4):1010428317697558
pubmed: 28443475
Cell. 2017 Feb 9;168(4):707-723
pubmed: 28187290
Sci Rep. 2015 Jul 24;5:12495
pubmed: 26205124
Cell Stem Cell. 2011 May 6;8(5):482-5
pubmed: 21549324
PLoS One. 2012;7(4):e36389
pubmed: 22558459
Cell. 1997 Jan 24;88(2):277-85
pubmed: 9008168
Mol Cell Biochem. 2012 Nov;370(1-2):45-51
pubmed: 22833359
Neoplasia. 2019 Jan;21(1):93-105
pubmed: 30529074
Clin Cancer Res. 2008 Mar 1;14(5):1340-8
pubmed: 18316553
Cell Prolif. 2016 Feb;49(1):69-78
pubmed: 26840372
Genome Biol. 2005;6(2):209
pubmed: 15693956
Cell. 2009 Feb 20;136(4):642-55
pubmed: 19239886
Nat Rev Drug Discov. 2010 Oct;9(10):775-89
pubmed: 20885409
Hepatology. 2011 Nov;54(5):1729-40
pubmed: 21793034
PLoS One. 2012;7(12):e50165
pubmed: 23272057
Oncotarget. 2014 Aug 30;5(16):6687-700
pubmed: 25149532
EMBO J. 2002 Sep 2;21(17):4663-70
pubmed: 12198168
Am J Cancer Res. 2016 Aug 01;6(8):1785-98
pubmed: 27648365
Development. 2016 Jul 1;143(13):2249-60
pubmed: 27381223
Mol Cancer. 2018 Feb 07;17(1):22
pubmed: 29415727
Cell Physiol Biochem. 2015;37(3):1123-33
pubmed: 26402430
Proc Natl Acad Sci U S A. 2009 Nov 17;106(46):19485-90
pubmed: 19887629
Med Oncol. 2017 Feb;34(2):20
pubmed: 28058628
Sci Rep. 2016 May 09;6:25602
pubmed: 27157642
Cell Physiol Biochem. 2016;40(1-2):62-76
pubmed: 27842308
Mol Pharm. 2011 Feb 7;8(1):250-9
pubmed: 21138272
Oncotarget. 2016 Nov 29;7(48):79805-79813
pubmed: 27806334
Cell Physiol Biochem. 2017;42(4):1431-1446
pubmed: 28715819
Angiogenesis. 2016 Apr;19(2):191-200
pubmed: 26899730
Cancer Res. 2001 May 15;61(10):4143-54
pubmed: 11358838
Anticancer Res. 2011 Nov;31(11):3859-63
pubmed: 22110210
Br J Cancer. 2015 Feb 17;112(4):624-9
pubmed: 25584492
Angiogenesis. 2017 Nov;20(4):409-426
pubmed: 28660302
Oncotarget. 2016 Apr 5;7(14):18247-61
pubmed: 26919096
Proc Natl Acad Sci U S A. 2000 Dec 19;97(26):14608-13
pubmed: 11121063
Genes Dev. 2014 May 15;28(10):1054-67
pubmed: 24788094
Genome Med. 2016 Oct 25;8(1):111
pubmed: 27782862
J Cell Mol Med. 2018 Jan;22(1):655-667
pubmed: 28984028
Oncotarget. 2015 Nov 10;6(35):37200-15
pubmed: 26468984
Clin Cancer Res. 2004 Jun 15;10(12 Pt 1):4109-17
pubmed: 15217947
Cancer Lett. 2014 Aug 28;351(1):151-61
pubmed: 24880079
Cancer Res. 2005 Feb 15;65(4):1414-24
pubmed: 15735029
Exp Ther Med. 2016 Dec;12(6):3837-3842
pubmed: 28105117
Dev Cell. 2012 Feb 14;22(2):418-29
pubmed: 22340502
J Biol Chem. 2008 Jun 6;283(23):15878-83
pubmed: 18417479
Mol Cell Biol. 2010 Aug;30(15):3902-13
pubmed: 20516212
Cancer Res. 2005 May 15;65(10):4353-61
pubmed: 15899827
Cancer Lett. 2016 Jun 1;375(2):331-339
pubmed: 27000664
Am J Pathol. 2002 Mar;160(3):985-1000
pubmed: 11891196
Cancer Microenviron. 2008 Dec;1(1):53-68
pubmed: 19308685
Oncogene. 2017 Jul 13;36(28):3986-4000
pubmed: 28288140
Circ Res. 2016 Jan 8;118(1):38-47
pubmed: 26472816
J Surg Res. 2003 May 1;111(1):91-9
pubmed: 12842453
Nat Genet. 2006 Sep;38(9):1060-5
pubmed: 16878133
Tumour Biol. 2015 May;36(5):3763-73
pubmed: 25731730
Atherosclerosis. 2011 Apr;215(2):286-93
pubmed: 21310411
Curr Opin Genet Dev. 2009 Jun;19(3):205-11
pubmed: 19446450
J Neurosurg. 2016 Oct;125(4):1008-1015
pubmed: 26799295
Med Oncol. 2012 Sep;29(3):1673-80
pubmed: 22052152
Cancer Lett. 2017 Jul 1;397:111-119
pubmed: 28365400
Cell Physiol Biochem. 2017;41(3):933-946
pubmed: 28222438
Cancer Metastasis Rev. 2018 Mar;37(1):45-53
pubmed: 29270700
Oncogene. 2008 Apr 3;27(15):2128-36
pubmed: 17968323
Philos Trans R Soc Lond B Biol Sci. 2017 May 19;372(1720):null
pubmed: 28348255
Science. 2001 Apr 20;292(5516):464-8
pubmed: 11292862
PLoS One. 2011 Apr 22;6(4):e19139
pubmed: 21544242
J Urol. 2012 Aug;188(2):615-23
pubmed: 22704449
Biosci Rep. 2017 May 19;37(3):null
pubmed: 28465356
Oncogene. 2014 Feb 6;33(6):679-89
pubmed: 23353819
Cancer Res. 2008 Jul 15;68(14):5540-5
pubmed: 18632605
Oncotarget. 2017 Jan 31;8(5):8162-8172
pubmed: 28030804
Cancer Res. 2005 Feb 1;65(3):1007-17
pubmed: 15705902
Dig Dis Sci. 2019 Mar;64(3):792-802
pubmed: 30465177
Semin Cancer Biol. 2009 Oct;19(5):329-37
pubmed: 19482086
Oncotarget. 2017 May 9;8(19):31153-31168
pubmed: 28415713
Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20350-5
pubmed: 18077375
J Cell Physiol. 2019 Feb;234(2):1099-1110
pubmed: 30070704
Biomed Res Int. 2015;2015:941980
pubmed: 26064968
Clin Cancer Res. 2014 Nov 15;20(22):5796-807
pubmed: 25212607
Dev Cell. 2008 Aug;15(2):261-71
pubmed: 18694565
Science. 1996 Jan 26;271(5248):509-12
pubmed: 8560266
Mol Cell Biochem. 2011 May;351(1-2):157-64
pubmed: 21249429
Gastroenterology. 2007 Aug;133(2):647-58
pubmed: 17681183
Curr Top Microbiol Immunol. 1999;246:31-7; discussion 38
pubmed: 10396036
Nature. 2005 Jun 9;435(7043):839-43
pubmed: 15944709
Nat Med. 2010 Aug;16(8):909-14
pubmed: 20676106
Nature. 2012 Feb 15;482(7385):347-55
pubmed: 22337054
Proc Natl Acad Sci U S A. 1990 Sep;87(17):6624-8
pubmed: 1697685
Nucleic Acids Res. 2011 Apr;39(8):3026-41
pubmed: 21149267
FEBS J. 2018 Apr;285(7):1359-1371
pubmed: 29474747
Cancer Res. 2006 Feb 1;66(3):1313-9
pubmed: 16452184
Mol Ther. 2015 Nov;23(11):1748-1758
pubmed: 26201448
Nature. 2012 Apr 04;484(7392):44-6
pubmed: 22481354
Cells. 2019 Sep 18;8(9):
pubmed: 31540455
Mol Med Rep. 2016 Jan;13(1):379-85
pubmed: 26572705
Science. 2004 Jan 2;303(5654):95-8
pubmed: 14631048
J Exp Clin Cancer Res. 2018 Oct 3;37(1):242
pubmed: 30285793
Oncol Rep. 2016 Mar;35(3):1696-702
pubmed: 26718330
Endocr Rev. 2004 Aug;25(4):581-611
pubmed: 15294883
J Urol. 2011 Sep;186(3):1077-83
pubmed: 21784468
Biochem Biophys Res Commun. 2016 Aug 26;477(3):461-6
pubmed: 27318091
Cell. 2009 Jan 23;136(2):215-33
pubmed: 19167326
Cancer Biol Ther. 2008 Feb;7(2):265-7
pubmed: 18347426
Cell. 2005 Jan 14;120(1):15-20
pubmed: 15652477
Gynecol Oncol. 2014 Jun;133(3):568-74
pubmed: 24680769
Oncol Rep. 2016 Nov;36(5):2553-2562
pubmed: 27666683
Transl Oncol. 2017 Aug;10(4):650-660
pubmed: 28668763
Oncogene. 2014 Jul 10;33(28):3636-47
pubmed: 24037526
Dev Biol. 2007 Oct 15;310(2):442-53
pubmed: 17765889
Oncogene. 2013 Jan 24;32(4):414-21
pubmed: 22391569
Cancer Cell. 2007 Jun;11(6):539-54
pubmed: 17560335
Neuro Oncol. 2014 Nov;16(11):1510-22
pubmed: 24951112
Tumour Biol. 2014 Dec;35(12):11879-85
pubmed: 25213694
Dev Cell. 2008 Aug;15(2):272-84
pubmed: 18694566
Cancer J. 2015 Jul-Aug;21(4):267-73
pubmed: 26222078
Cancer Res. 1994 Aug 15;54(16):4539-46
pubmed: 7519124
Lab Med. 2019 Oct 10;50(4):333-347
pubmed: 31049571
Science. 2002 Jan 4;295(5552):140-3
pubmed: 11778052
Genes Cancer. 2011 Dec;2(12):1106-16
pubmed: 22866202
Mol Cancer. 2014 Mar 20;13:63
pubmed: 24650032
Breast Cancer Res Treat. 2009 Sep;117(1):131-40
pubmed: 18932017
J Clin Invest. 2008 May;118(5):1944-54
pubmed: 18398510
Semin Cancer Biol. 2015 Dec;35 Suppl:S224-S243
pubmed: 25600295
Cell Mol Biol Lett. 2016 Jul 28;21:3
pubmed: 28536606
Biomed Res Int. 2015;2015:549412
pubmed: 26146622
Cancer Biomark. 2016;16(3):385-94
pubmed: 26889816
Nat Rev Cancer. 2003 Jun;3(6):401-10
pubmed: 12778130
Carcinogenesis. 2000 Mar;21(3):505-15
pubmed: 10688871
J Cell Physiol. 2019 Dec;234(12):22272-22284
pubmed: 31106423
Cancer Manag Res. 2018 Aug 02;10:2429-2437
pubmed: 30122992
J Cell Mol Med. 2019 Jan;23(1):556-567
pubmed: 30467960
Curr Cancer Drug Targets. 2018;18(3):266-277
pubmed: 28669338
Nature. 2000 Sep 14;407(6801):249-57
pubmed: 11001068
Nat Rev Cancer. 2006 Nov;6(11):857-66
pubmed: 17060945
Ann N Y Acad Sci. 2017 Sep;1404(1):27-48
pubmed: 28833193
Blood. 2006 Nov 1;108(9):3068-71
pubmed: 16849646
Cell. 2010 Jun 25;141(7):1195-207
pubmed: 20603000
Cancer Biol Ther. 2008 Feb;7(2):255-64
pubmed: 18059191
Cancer Cell. 2008 Nov 4;14(5):382-93
pubmed: 18977327
PLoS One. 2013 Sep 09;8(9):e73940
pubmed: 24040120
Arterioscler Thromb Vasc Biol. 2010 Aug;30(8):1562-8
pubmed: 20489169
Mol Oncol. 2014 Sep 12;8(6):1132-9
pubmed: 25106088
Gene. 2017 Jun 5;615:42-49
pubmed: 28323002