Modified ketogenic diet is associated with improved cerebrospinal fluid biomarker profile, cerebral perfusion, and cerebral ketone body uptake in older adults at risk for Alzheimer's disease: a pilot study.
Aged
Alzheimer Disease
/ diagnosis
Amyloid beta-Peptides
/ cerebrospinal fluid
Biomarkers
/ cerebrospinal fluid
Cerebrovascular Circulation
Cross-Over Studies
Diet, Mediterranean
Female
Humans
Ketone Bodies
/ metabolism
Male
Memory
Middle Aged
Peptide Fragments
/ cerebrospinal fluid
Pilot Projects
Risk
Alzheimer's disease
CSF biomarkers
Ketogenic diet
MRI
Mild cognitive impairment
PET
Journal
Neurobiology of aging
ISSN: 1558-1497
Titre abrégé: Neurobiol Aging
Pays: United States
ID NLM: 8100437
Informations de publication
Date de publication:
02 2020
02 2020
Historique:
received:
23
05
2019
revised:
21
09
2019
accepted:
22
09
2019
pubmed:
24
11
2019
medline:
8
9
2020
entrez:
24
11
2019
Statut:
ppublish
Résumé
There is currently no established therapy to treat or prevent Alzheimer's disease. The ketogenic diet supplies an alternative cerebral metabolic fuel, with potential neuroprotective effects. Our goal was to compare the effects of a modified Mediterranean-ketogenic diet (MMKD) and an American Heart Association Diet (AHAD) on cerebrospinal fluid Alzheimer's biomarkers, neuroimaging measures, peripheral metabolism, and cognition in older adults at risk for Alzheimer's. Twenty participants with subjective memory complaints (n = 11) or mild cognitive impairment (n = 9) completed both diets, with 3 participants discontinuing early. Mean compliance rates were 90% for MMKD and 95% for AHAD. All participants had improved metabolic indices following MMKD. MMKD was associated with increased cerebrospinal fluid Aβ42 and decreased tau. There was increased cerebral perfusion and increased cerebral ketone body uptake (
Identifiants
pubmed: 31757576
pii: S0197-4580(19)30336-7
doi: 10.1016/j.neurobiolaging.2019.09.015
pmc: PMC7266642
mid: NIHMS1576734
pii:
doi:
Substances chimiques
Amyloid beta-Peptides
0
Biomarkers
0
Ketone Bodies
0
Peptide Fragments
0
amyloid beta-protein (1-42)
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
54-63Subventions
Organisme : NIA NIH HHS
ID : P30 AG049638
Pays : United States
Informations de copyright
Copyright © 2019. Published by Elsevier Inc.
Références
J Cereb Blood Flow Metab. 2014 Jun;34(6):964-70
pubmed: 24619276
Neuroimage. 2003 Jul;19(3):1233-9
pubmed: 12880848
J Alzheimers Dis. 2019;68(3):969-981
pubmed: 30856112
J Child Neurol. 2013 Aug;28(8):1027-33
pubmed: 23670253
Acta Neuropathol. 2018 Sep;136(3):363-376
pubmed: 29700597
Neurobiol Aging. 2011 Jul;32(7):1207-18
pubmed: 19660834
Neurosci Biobehav Rev. 2017 Jan;72:168-175
pubmed: 27908711
Annu Rev Pathol. 2010;5:297-348
pubmed: 20078222
PLoS One. 2013 Sep 12;8(9):e75713
pubmed: 24069439
Alzheimers Dement (N Y). 2017 Dec 06;4:28-36
pubmed: 29955649
Neurobiol Aging. 2014 Jun;35(6):1386-95
pubmed: 24388785
Radiology. 2009 Mar;250(3):856-66
pubmed: 19164119
BMC Med. 2014 May 13;12:78
pubmed: 24886626
J Child Neurol. 2000 Dec;15(12):787-90
pubmed: 11198492
Obesity (Silver Spring). 2013 Jul;21(7):1313-20
pubmed: 23687103
Nat Rev Neurosci. 2011 May;12(5):284-96
pubmed: 21448224
J Magn Reson Imaging. 2009 May;29(5):1134-9
pubmed: 19388118
Am J Epidemiol. 2012 Oct 1;176 Suppl 7:S44-54
pubmed: 23035144
Neurobiol Aging. 2014 Mar;35(3):600-13
pubmed: 24210253
Neurobiol Aging. 2015 Jul;36(7):2296-2303
pubmed: 25896951
Am J Physiol Endocrinol Metab. 2014 Jun 1;306(11):E1315-21
pubmed: 24735889
J Alzheimers Dis. 2010;20(3):871-80
pubmed: 20413865
Annu Rev Nutr. 2006;26:1-22
pubmed: 16848698
Neurology. 2005 Jan 25;64(2):277-81
pubmed: 15668425
Front Pharmacol. 2012 Apr 09;3:59
pubmed: 22509165
Nutr Metab (Lond). 2009 Aug 10;6:31
pubmed: 19664276
J Neurochem. 2015 Jul;134(1):7-20
pubmed: 25832906
Alzheimers Dement. 2011 May;7(3):270-9
pubmed: 21514249
JAMA Neurol. 2016 Jan;73(1):60-7
pubmed: 26524180
Alzheimer Dis Assoc Disord. 2010 Jul-Sep;24(3):284-90
pubmed: 20683186
J Alzheimers Dis. 2015;43(4):1343-53
pubmed: 25147107
Epilepsia. 2007 Jan;48(1):31-42
pubmed: 17241206
Brain Res Rev. 2009 Mar;59(2):293-315
pubmed: 18845187
Brain Res. 2013 Apr 10;1505:61-7
pubmed: 23415649
Neuroimage. 2011 Mar 15;55(2):468-78
pubmed: 21167947
Arch Neurol. 2009 Mar;66(3):300-5
pubmed: 19273747
Exp Gerontol. 2018 Jul 1;107:18-26
pubmed: 28709938
Arch Neurol. 2011 Jun;68(6):743-52
pubmed: 21670398
Pediatrics. 2007 Mar;119(3):535-43
pubmed: 17332207
J Nutr. 2001 Jan;131(1):132-46
pubmed: 11208950
Alzheimers Res Ther. 2014 Jul 03;6(4):37
pubmed: 25024750
Ann Intern Med. 2004 May 18;140(10):769-77
pubmed: 15148063
J Alzheimers Dis. 2018;62(3):1125-1140
pubmed: 29562534
Nitric Oxide. 2011 Jan 1;24(1):34-42
pubmed: 20951824
Alzheimers Dement. 2015 Dec;11(12):1417-1429
pubmed: 25960448
Neurobiol Aging. 2016 Mar;39:25-37
pubmed: 26923399
Arch Neurol. 2007 Jan;64(1):93-6
pubmed: 17210814
Ann Neurol. 2006 Aug;60(2):223-35
pubmed: 16807920
Neurobiol Aging. 2012 Feb;33(2):425.e19-27
pubmed: 21130529
Am J Psychiatry. 1984 Nov;141(11):1356-64
pubmed: 6496779
Neurobiol Aging. 2004 Mar;25(3):311-4
pubmed: 15123336
Magn Reson Med. 2010 Sep;64(3):799-810
pubmed: 20578056
Neurol Neuroimmunol Neuroinflamm. 2018 Nov 07;6(1):e512
pubmed: 30568991
Neuroimage Clin. 2017 Nov 09;17:628-641
pubmed: 29234599
Nutr Metab (Lond). 2005 Oct 17;2:28
pubmed: 16229744
J Alzheimers Dis. 2016 Oct 4;54(3):1061-1072
pubmed: 27567835
Clin Diabetes. 2016 Jan;34(1):3-21
pubmed: 26807004
Magn Reson Med. 2008 Dec;60(6):1362-71
pubmed: 18828149
PLoS One. 2011;6(7):e21788
pubmed: 21747957
Lancet Neurol. 2017 Apr;16(4):311-322
pubmed: 28327340
Neurobiol Aging. 2013 Jun;34(6):1530-9
pubmed: 23276384
PLoS One. 2013;8(2):e56733
pubmed: 23437228
Neurotherapeutics. 2009 Apr;6(2):406-14
pubmed: 19332337
Magn Reson Med. 1998 Sep;40(3):383-96
pubmed: 9727941
Neurology. 2008 Sep 30;71(14):1057-64
pubmed: 18367704