Control of Regulatory T Cells by Co-signal Molecules.

Forkhead Transcription Factors / metabolism Homeostasis Humans Signal Transduction T-Lymphocytes, Regulatory / cytology
CD27 CD28 CD30 CTLA-4 DR3 GITR ICOS OX40 PD-1 TIGIT TNFR2 Tim-3 Tregs

Journal

Advances in experimental medicine and biology
ISSN: 0065-2598
Titre abrégé: Adv Exp Med Biol
Pays: United States
ID NLM: 0121103

Informations de publication

Date de publication:
2019
Historique:
entrez: 24 11 2019
pubmed: 24 11 2019
medline: 4 12 2019
Statut: ppublish

Résumé

Foxp3-expressing regulatory T cells (Tregs) perform a vital function in the maintenance of immune homeostasis. A large part of Treg suppressive function is derived from their ability to control and restrict the availability of co-signal molecules to other T cells. However, Tregs themselves also depend on many of the same co-signals for their own homeostasis, making this a complex system of feedback. In this chapter, we discuss the critical role of co-signaling in Treg cell biology.

Identifiants

DOI: 10.1007/978-981-32-9717-3_7 PMID: 31758535
pubmed: 31758535
doi: 10.1007/978-981-32-9717-3_7
doi:

Substances chimiques

FOXP3 protein, human 0
Forkhead Transcription Factors 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

179-210

Auteurs

James Badger Wing (JB)

Laboratory of Experimental Immunology, WPI Immunology Frontier Research Center (IFReC), Osaka University, Osaka, Japan.

Christopher Tay (C)

Laboratory of Experimental Immunology, WPI Immunology Frontier Research Center (IFReC), Osaka University, Osaka, Japan.

Shimon Sakaguchi (S)

Laboratory of Experimental Immunology, WPI Immunology Frontier Research Center (IFReC), Osaka University, Osaka, Japan. shimon@ifrec.osaka-u.ac.jp.
Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan. shimon@ifrec.osaka-u.ac.jp.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription à motif hélice ailée › Facteurs de transcription Forkhead › Control of Regulatory T Cells by Co-signal Molecules.
questionsmedicales.fr › Phénomènes physiologiques › Homéostasie › Control of Regulatory T Cells by Co-signal Molecules.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Control of Regulatory T Cells by Co-signal Molecules.
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Control of Regulatory T Cells by Co-signal Molecules.
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Sous-populations de lymphocytes T › Lymphocytes T régulateurs › Control of Regulatory T Cells by Co-signal Molecules.