Microsporidial keratopathy in two dogs.
Nosema
canine
dog
keratopathy
microsporidial
microsporidium
Journal
Veterinary ophthalmology
ISSN: 1463-5224
Titre abrégé: Vet Ophthalmol
Pays: England
ID NLM: 100887377
Informations de publication
Date de publication:
Mar 2020
Mar 2020
Historique:
received:
10
06
2019
revised:
07
09
2019
accepted:
28
10
2019
pubmed:
24
11
2019
medline:
7
1
2021
entrez:
24
11
2019
Statut:
ppublish
Résumé
A microsporidial keratopathy is described in two dogs. Both dogs presented with a unilateral stromal keratopathy characterized by multifocal coalescing opacities, and the diagnosis was made on histopathologic examination of keratectomy specimens. Transmission electron microscopy (TEM) on formalin-fixed, paraffin-embedded corneal tissue was performed in one dog, and the morphologic features were consistent with Nosema species infection. Both dogs were initially diagnosed and treated by superficial keratectomy. One dog received additional antifungal medication and underwent a penetrating keratoplasty following local recurrence two years later. No other systemic lesions attributable to the microsporidial infection were identified clinically. The clinical and diagnostic pathology findings, treatment, and follow-up are discussed.
Substances chimiques
Antifungal Agents
0
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
402-408Informations de copyright
© 2019 American College of Veterinary Ophthalmologists.
Références
Hirt RP, Logsdon Jr JM, Healy B, Dorey MW, Doolittle WF, Embley TM. Microsporidia are related to Fungi: evidence from the largest subunit of RNA polymerase II and other proteins. Proc Natl Acad Sci U S A. 1999;96(2):580-585.
Wasson K, Peper RL. Mammalian microsporidiosis. Vet Pathol. 2000;37(2):113-128.
Weber R, Bryan RT, Schwartz DA, Owen RL. Human microsporidial infections. Clin Microbiol Rev. 1994;7(4):426-461.
Curry A. Human microsporidial infection and possible animal sources. Curr Opin Infect Dis. 1999;12(5):473-480.
Curry A, Mudhar HS, Dewan S, Canning EU, Wagner BE. A case of bilateral microsporidial keratitis from Bangladesh-infection by an insect parasite from the genus Nosema. J Med Microbiol. 2007;56(Pt 9):1250-1252.
Ashton N, Cook C, Clegg F. Encephalitozoonosis (nosematosis) causing bilateral cataract in a rabbit. Br J Ophthalmol. 1976;60(9):618-631.
Felchle LM, Sigler RL. Phacoemulsification for the management of Encephalitozoon cuniculi-induced phacoclastic uveitis in a rabbit. Vet Ophthalmol. 2002;5(3):211-215.
Giordano C, Weigt A, Vercelli A, Rondena M, Grilli G, Giudice C. Immunohistochemical identification of Encephalitozoon cuniculi in phacoclastic uveitis in four rabbits. Vet Ophthalmol. 2005;8(4):271-275.
Benz P, Maass G, Csokai J, et al. Detection of Encephalitozoon cuniculi in the feline cataractous lens. Vet Ophthalmol. 2011;1:37-47.
Nell B, Csokai J, Fuchs-Baumgartinger A, Maass G. Encephalitozoon cuniculi causes focal anterior cataract and uveitis in dogs. Tierarztl Prax Ausg K Kleintiere Heimtiere. 2015;43(5):337-344.
Scurrell EJ, Holding E, Hopper J, et al. Bilateral lenticular Encephalitozoon cuniculi infection in a snow leopard (Panthera uncia). Vet Ophthalmol. 2015;18(suppl 1):143-147.
Arnesen K, Nordstoga K. Ocular encephalitozoonosis (nosematosis) in blue foxes. Polyarteritis nodosa and cataract. Acta Ophthalmol (Copenh). 1977;55(4):641-651.
Bjerkas I. Brain and spinal cord lesions in encephalitozoonosis in mink. Acta Vet Scand. 1990;31(4):423-432.
Canny CJ, Ward DA, Patton S, Orosz S. Microsporidian keratoconjunctivitis in a double yellow-headed amazon parrot (Amazona ochrocephala oratrix). J Avian Med Surg. 1999;13(13):279-286.
Phalen DN, Logan KS, Snowden KF. Encephalitozoon hellem infection as the cause of a unilateral chronic keratoconjunctivitis in an umbrella cockatoo (Cacatua alba). Vet Ophthalmol. 2006;9(1):59-63.
Rauz S, Tuft S, Dart JK, Bonshek R, Luthert P, Curry A. Ultrastructural examination of two cases of stromal microsporidial keratitis. J Med Microbiol. 2004;53(Pt 8):775-781.
Vemuganti GK, Garg P, Sharma S, Joseph J, Gopinathan U, Singh S. Is Microsporidial keratitis an emerging cause of stromal keratitis? - a case series study. BMC Ophthalmol. 2005;5:19.
Alkatan HM, Al-Zaaidi S, Athmanathan S. Microsporidial keratitis: Literature review and report of 2 cases in a tertiary eye care center. Saudi J Ophthalmol. 2012;26(2):199-203.
Ang M, Mehta JS, Mantoo S, Tan D. Deep anterior lamellar keratoplasty to treat microsporidial stromal keratitis. Cornea. 2009;28(7):832-835.
Didier ES, Didier PJ, Friedberg DN, et al. Isolation and characterization of a new human microsporidian, Encephalitozoon hellem (n. sp.), from three AIDS patients with keratoconjunctivitis. J Infect Dis. 1991;163(3):617-621.
Font RL, Su GW, Matoba AY. Microsporidial stromal keratitis. Arch Ophthalmol. 2003;121(7):1045-1047.
Cali A, Meisler DM, Lowder CY, et al. Corneal microsporidioses: characterization and identification. J Protozool. 1991;38(6):215S-217S.
Mietz H, Franzen C, Hoppe T, Bartz-Schmidt KU. Microsporidia-induced sclerouveitis with retinal detachment. Arch Ophthalmol. 2002;120(6):864-865.
Yoken J, Forbes B, Maguire AM, Prenner JL, Carpentieri D. Microsporidial endophthalmitis in a patient with acute myelogenous leukemia. Retina. 2002;22(1):123-125.
Coca M, Kim J, Shenoy S, Chevez-Barrios P, Kapur M. Microsporidial stromal keratitis: successful treatment with topical voriconazole and oral itraconazole. Cureus. 2016;8(12):e934.
Trammer T, Chioralia G, Maier WA, Seitz HM. In vitro replication of Nosema algerae (Microsporidia), a parasite of anopheline mosquitoes, in human cells above 36 degrees C. J Eukaryot Microbiol. 1999;46(5):464-468.
Shah GK, Pfister D, Probst LE, Ferrieri P, Holland E. Diagnosis of microsporidial keratitis by confocal microscopy and the chromatrope stain. Am J Ophthalmol. 1996;121(1):89-91.
Garcia LS. Laboratory identification of the microsporidia. J Clin Microbiol. 2002;40(6):1892-1901.
Cali A, Meisler DM, Rutherford I, et al. Corneal microsporidiosis in a patient with AIDS. Am J Trop Med Hyg. 1991;44(5):463-468.
Bommala ML, Nalamada S, Sharma S, Garg P. Microsporidial keratoconjunctivitis in an immunocompetent patient with a past history of laser in situ keratomilieusis surgery. Indian J Med Microbiol. 2011;29(4):428-430.
Chan CM, Theng JT, Li L, Tan DT. Microsporidial keratoconjunctivitis in healthy individuals: a case series. Ophthalmology. 2003;110(7):1420-1425.
Khandelwal SS, Woodward MA, Hall T, Grossniklaus HE, Stulting RD. Treatment of microsporidia keratitis with topical voriconazole monotherapy. Arch Ophthalmol. 2011;129(4):509-510.
Sangit VA, Murthy SI, Garg P. Microsporidial stromal keratitis successfully treated with medical therapy: a case report. Cornea. 2011;30(11):1264-1266.
Font RL, Samaha AN, Keener MJ, Chevez-Barrios P, Goosey JD. Corneal microsporidiosis. Report of case, including electron microscopic observations. Ophthalmology. 2000;107(9):1769-1775.