Association of iron levels in hair with brain structures and functions in young adults.
Diffusion tensor imaging
Hair minerals
Hippocampus
Iron
Perfusion
Regional gray matter volume
Journal
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)
ISSN: 1878-3252
Titre abrégé: J Trace Elem Med Biol
Pays: Germany
ID NLM: 9508274
Informations de publication
Date de publication:
Mar 2020
Mar 2020
Historique:
received:
28
04
2019
revised:
02
11
2019
accepted:
12
11
2019
pubmed:
25
11
2019
medline:
9
10
2020
entrez:
25
11
2019
Statut:
ppublish
Résumé
Iron plays a critical role in normal brain functions and development, but it has also been known to have adverse neurological effects. Here, we investigated the associations of iron levels in hair with regional gray matter volume (rGMV), regional cerebral blood flow (rCBF), fractional anisotropy (FA), mean diffusivity (MD), and cognitive differences in a study cohort of 590 healthy young adults. Our findings showed that high iron levels were associated with lower rGMV in areas including the hippocampus, lower rCBF in the anterior and posterior parts of the brain, greater FA in areas including the part of the splenium of the corpus callosum, lower MD in the overlapping area including the splenium of the corpus callosum, as well as greater MD in the left hippocampus and areas including the frontal lobe. These results are compatible with the notion that iron plays diverse roles in neural mechanisms in healthy young adults.
Sections du résumé
BACKGROUND
BACKGROUND
Iron plays a critical role in normal brain functions and development, but it has also been known to have adverse neurological effects.
METHODS
METHODS
Here, we investigated the associations of iron levels in hair with regional gray matter volume (rGMV), regional cerebral blood flow (rCBF), fractional anisotropy (FA), mean diffusivity (MD), and cognitive differences in a study cohort of 590 healthy young adults.
RESULTS
RESULTS
Our findings showed that high iron levels were associated with lower rGMV in areas including the hippocampus, lower rCBF in the anterior and posterior parts of the brain, greater FA in areas including the part of the splenium of the corpus callosum, lower MD in the overlapping area including the splenium of the corpus callosum, as well as greater MD in the left hippocampus and areas including the frontal lobe.
CONCLUSION
CONCLUSIONS
These results are compatible with the notion that iron plays diverse roles in neural mechanisms in healthy young adults.
Identifiants
pubmed: 31760327
pii: S0946-672X(19)30283-4
doi: 10.1016/j.jtemb.2019.126436
pii:
doi:
Substances chimiques
Iron
E1UOL152H7
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
126436Informations de copyright
Copyright © 2019 Elsevier GmbH. All rights reserved.