The increased neopterin content in turkish pediatric patients with sickle cell anemia.
Biopterin
Kynurenine
Neopterin
Sickle cell Anemia
Tryptophan
Journal
Annals of hematology
ISSN: 1432-0584
Titre abrégé: Ann Hematol
Pays: Germany
ID NLM: 9107334
Informations de publication
Date de publication:
Jan 2020
Jan 2020
Historique:
received:
27
03
2019
accepted:
05
10
2019
pubmed:
25
11
2019
medline:
15
1
2020
entrez:
25
11
2019
Statut:
ppublish
Résumé
In the present study, the possible activation of cellular immunity in SCD patients was investigated. As immune activation parameters, neopterin concentrations and kynurenine/tryptophan ratio for tryptophan degradation in 35 pediatric patients with sickle cell disease (31 HbSS and 4 HbSß) were determined. Our results have shown that neopterin levels (both urinary and serum) are increased in pediatric patients with sickle cell disease. The increase in neopterin concentration was accompanied by significantly increased biopterin, kynurenine concentration and kynurenine/tryptophan ratio. The mechanism of immune activation and the effects of inflammatory mediators in sickle cell disease are poorly understood, especially in terms of cell-mediated immunity. Further in-vivo and in-vitro studies are required to illuminate the association between neopterin levels and neutrophil activation in sickle cell disease.
Identifiants
pubmed: 31760485
doi: 10.1007/s00277-019-03817-5
pii: 10.1007/s00277-019-03817-5
doi:
Substances chimiques
Neopterin
670-65-5
Types de publication
Clinical Trial
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
41-47Références
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