Genome-wide Associations Reveal Human-Mouse Genetic Convergence and Modifiers of Myogenesis, CPNE1 and STC2.

Adult Aged Aging Animals Body Composition / genetics Body Weight Calcium-Binding Proteins / genetics Case-Control Studies Female Follow-Up Studies Genome-Wide Association Study Glycoproteins / genetics Humans Intercellular Signaling Peptides and Proteins / genetics Male Mice Middle Aged Muscle Development / genetics Muscle, Skeletal / cytology Quantitative Trait Loci Thinness / genetics
UK Biobank human and mouse GWAS sarcopenia skeletal muscle

Journal

American journal of human genetics
ISSN: 1537-6605
Titre abrégé: Am J Hum Genet
Pays: United States
ID NLM: 0370475

Informations de publication

Date de publication:
05 12 2019
Historique:
received: 02 05 2019
accepted: 28 10 2019
pubmed: 26 11 2019
medline: 3 4 2020
entrez: 26 11 2019
Statut: ppublish

Résumé

Muscle bulk in adult healthy humans is highly variable even after height, age, and sex are accounted for. Low muscle mass, due to fewer and/or smaller constituent muscle fibers, would exacerbate the impact of muscle loss occurring in aging or disease. Genetic variability substantially influences muscle mass differences, but causative genes remain largely unknown. In a genome-wide association study (GWAS) on appendicular lean mass (ALM) in a population of 85,750 middle-aged (aged 38-49 years) individuals from the UK Biobank (UKB), we found 182 loci associated with ALM (p < 5 × 10

Identifiants

DOI: 10.1016/j.ajhg.2019.10.014 PMID: 31761296 PMC: PMC6904802
pubmed: 31761296
pii: S0002-9297(19)30402-1
doi: 10.1016/j.ajhg.2019.10.014
pmc: PMC6904802
pii:
doi:

Substances chimiques

CPNE1 protein, human 0
Calcium-Binding Proteins 0
Glycoproteins 0
Intercellular Signaling Peptides and Proteins 0
STC2 protein, human 0
Stc2 protein, mouse 0
copine1 protein, mouse 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1222-1236

Subventions

Organisme : Medical Research Council
ID : MC_QA137853
Pays : United Kingdom
Organisme : NIMH NIH HHS
ID : T32 MH020065
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR056280
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM007197
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA021336
Pays : United States
Organisme : NHGRI NIH HHS
ID : R01 HG002899
Pays : United States
Organisme : Medical Research Council
ID : MC_PC_17228
Pays : United Kingdom
Organisme : NIDA NIH HHS
ID : R21 DA024845
Pays : United States

Commentaires et corrections

Type : ErratumIn

Informations de copyright

Copyright © 2019 American Society of Human Genetics. Published by Elsevier Inc. All rights reserved.

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Auteurs

Ana I Hernandez Cordero (AI)

School of Medicine, Medical Sciences, and Nutrition, College of Life Sciences and Medicine, University of Aberdeen, Aberdeen, UK AB24 3FX, UK.

Natalia M Gonzales (NM)

Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA.

Clarissa C Parker (CC)

Department of Psychology, Middlebury College, Middlebury, VT 05753, USA; Program in Neuroscience, Middlebury College, Middlebury, VT, 05753, USA.

Greta Sokolof (G)

Department of Psychological and Brain Sciences, The University of Iowa, Iowa City, IA 52242, USA.

David J Vandenbergh (DJ)

Department of Biobehavioral Health, Penn State Institute for the Neurosciences, and Molecular, Cellular, and Integrative Sciences Program, Pennsylvania State University, University Park, PA 16802, USA.

Riyan Cheng (R)

Department of Health Sciences, University of California San Diego, La Jolla, CA 92093, USA.

Mark Abney (M)

Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA.

Andrew Sko (A)

Department of Medicine, University of Chicago, Chicago, IL 60637, USA.

Alex Douglas (A)

Institute of Biological and Environmental Sciences, University of Aberdeen, Aberdeen, AB24 3FX, UK.

Abraham A Palmer (AA)

Department of Psychiatry, University of California San Diego, La Jolla, CA 92093, USA; Institute for Genomic Medicine, University of California San Diego, La Jolla, CA 92093, USA.

Jennifer S Gregory (JS)

School of Medicine, Medical Sciences, and Nutrition, College of Life Sciences and Medicine, University of Aberdeen, Aberdeen, UK AB24 3FX, UK.

Arimantas Lionikas (A)

School of Medicine, Medical Sciences, and Nutrition, College of Life Sciences and Medicine, University of Aberdeen, Aberdeen, UK AB24 3FX, UK. Electronic address: a.lionikas@abdn.ac.uk.

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