Epidemiological and immunochemical parameters of monoclonal plasma cell dyscrasias of 2121 cases in Algeria.
Adolescent
Adult
Aged
Aged, 80 and over
Algeria
/ epidemiology
Child
Comorbidity
Female
Humans
Immunoglobulin Isotypes
/ blood
Immunoglobulin Light Chains
/ blood
Immunoglobulin M
/ blood
Male
Middle Aged
Monoclonal Gammopathy of Undetermined Significance
/ blood
Multiple Myeloma
/ blood
Paraproteinemias
/ blood
Paraproteins
/ analysis
Retrospective Studies
Sex Distribution
Young Adult
Monoclonal immunoglobulin
Plasma cell dyscrasias
Serum immunofixation
Serum protein electrophoresis
Journal
Current research in translational medicine
ISSN: 2452-3186
Titre abrégé: Curr Res Transl Med
Pays: France
ID NLM: 101681234
Informations de publication
Date de publication:
04 2020
04 2020
Historique:
received:
14
08
2019
revised:
13
10
2019
accepted:
11
11
2019
pubmed:
26
11
2019
medline:
20
8
2021
entrez:
26
11
2019
Statut:
ppublish
Résumé
Plasma cell dyscrasias (PCD) are a heterogeneous group of diseases characterized by the expansion of monoclonal bone marrow plasma cells that produce a monoclonal immunoglobulin (M-component). This is a retrospective study that describes the epidemiological, immunochemical features and etiology of monoclonal gammopathies diagnosed between 1998 and 2016 in the Teaching Hospital Beni-Messous of Algiers. 2121 cases of monoclonal gammopathies (MG) were collected during this period. Serum/urine protein electrophoresis, serum/urine immunofixation and serum free light chain measurements were used to demonstrate M protein. The middle age of the patients at the time of the diagnosis were 62.96 ± 13.19 years with extremes ranging from 07 to 99 years. The study included 1013 (47, 76 %) men and 1108 (52, 23 %) women with a sex ratio 0,91. Isotypes repartition was: IgG (60.91 %), IgA (17.91 %), light chain (10.46 %), IgM (6.6 %), IgD (1.03 %) and IgE (0.09 %) of cases. The most frequent diagnosis was: Multiple Myeloma (55.20 %), followed by monoclonal gammopathy of undetermined significance (34.13 %). In our study, two particularities were noted. There is no male predominance in Algerian PCD patients. Moreover, we observed a higher frequency of light chain multiple myeloma and lower frequency of IgM isotype compared to western studies.
Sections du résumé
BACKGROUND
Plasma cell dyscrasias (PCD) are a heterogeneous group of diseases characterized by the expansion of monoclonal bone marrow plasma cells that produce a monoclonal immunoglobulin (M-component).
PURPOSE
This is a retrospective study that describes the epidemiological, immunochemical features and etiology of monoclonal gammopathies diagnosed between 1998 and 2016 in the Teaching Hospital Beni-Messous of Algiers.
PATIENTS AND METHODS
2121 cases of monoclonal gammopathies (MG) were collected during this period. Serum/urine protein electrophoresis, serum/urine immunofixation and serum free light chain measurements were used to demonstrate M protein.
RESULTS
The middle age of the patients at the time of the diagnosis were 62.96 ± 13.19 years with extremes ranging from 07 to 99 years. The study included 1013 (47, 76 %) men and 1108 (52, 23 %) women with a sex ratio 0,91. Isotypes repartition was: IgG (60.91 %), IgA (17.91 %), light chain (10.46 %), IgM (6.6 %), IgD (1.03 %) and IgE (0.09 %) of cases. The most frequent diagnosis was: Multiple Myeloma (55.20 %), followed by monoclonal gammopathy of undetermined significance (34.13 %).
CONCLUSION
In our study, two particularities were noted. There is no male predominance in Algerian PCD patients. Moreover, we observed a higher frequency of light chain multiple myeloma and lower frequency of IgM isotype compared to western studies.
Identifiants
pubmed: 31761679
pii: S2452-3186(19)30045-5
doi: 10.1016/j.retram.2019.11.003
pii:
doi:
Substances chimiques
Immunoglobulin Isotypes
0
Immunoglobulin Light Chains
0
Immunoglobulin M
0
Paraproteins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
67-70Informations de copyright
Copyright © 2019 Elsevier Masson SAS. All rights reserved.