Selective catecholamine detection in living cells by a copper-mediated oxidative bond cleavage.
Journal
Chemical science
ISSN: 2041-6520
Titre abrégé: Chem Sci
Pays: England
ID NLM: 101545951
Informations de publication
Date de publication:
07 Oct 2019
07 Oct 2019
Historique:
received:
05
07
2019
accepted:
10
08
2019
entrez:
26
11
2019
pubmed:
26
11
2019
medline:
26
11
2019
Statut:
epublish
Résumé
The development of a new triggered-release system for selective detection of catecholamines in biological samples including living cells is reported. Catecholamines are a class of tightly regulated hormones and neurotransmitters in the human body and their dysregulation is implicated in various neurodegenerative diseases. It is highly challenging to selectively sense and detect catecholamines in a complex biological environment due to their small size, non-specific molecular shape and trivial chemical properties. In this study, a copper-based, catecholamine-triggered oxidation that releases a fluorescent reporter is described. The probe is highly sensitive and selective for detecting changes in catecholamine levels in aqueous buffer, human plasma, and cellular models of neuronal differentiation and Parkinson's disease. This new catecholamine sensing strategy features chemical reactivity as part of small molecule recognition as opposed to the conventional use of a well-designed host for reversible binding.
Identifiants
pubmed: 31762971
doi: 10.1039/c9sc03338f
pii: c9sc03338f
pmc: PMC6855198
doi:
Types de publication
Journal Article
Langues
eng
Pagination
8519-8526Informations de copyright
This journal is © The Royal Society of Chemistry 2019.
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