Myogenic differentiation of human amniotic mesenchymal cells and its tissue repair capacity on volumetric muscle loss.
Human amniotic mesenchymal cells
myogenic differentiation
tissue engineering
volumetric muscle loss
Journal
Journal of tissue engineering
ISSN: 2041-7314
Titre abrégé: J Tissue Eng
Pays: England
ID NLM: 101550131
Informations de publication
Date de publication:
Historique:
received:
14
08
2019
accepted:
17
10
2019
entrez:
26
11
2019
pubmed:
26
11
2019
medline:
26
11
2019
Statut:
epublish
Résumé
Stem cell-based tissue engineering therapy is the most promising method for treating volumetric muscle loss. Human amniotic mesenchymal cells possess characteristics similar to those of embryonic stem cells. In this study, we verified the stem cell characteristics of human amniotic mesenchymal cells by the flow cytometry analysis, and osteogenic and adipogenic differentiation. Through induction with the DNA demethylating agent 5-azacytidine, human amniotic mesenchymal cells can undergo myogenic differentiation and express skeletal muscle cell-specific markers such as desmin and MyoD. The Wnt/β-catenin signaling pathway also plays an important role. After 5-azacytidine-induced human amniotic mesenchymal cells were implanted into rat tibialis anterior muscle with volumetric muscle loss, we observed increased angiogenesis and improved local tissue repair. We believe that human amniotic mesenchymal cells can serve as a potential source of cells for skeletal muscle tissue engineering.
Identifiants
pubmed: 31762985
doi: 10.1177/2041731419887100
pii: 10.1177_2041731419887100
pmc: PMC6851610
doi:
Types de publication
Journal Article
Langues
eng
Pagination
2041731419887100Informations de copyright
© The Author(s) 2019.
Déclaration de conflit d'intérêts
Declaration of conflicting interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
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