Does Separate Administration of Montelukast and Levocetirizine Provide Better Results in Perennial Allergic Rhinitis: A Hospital Based Study.
Levocetirizine
Montelukast
PAR
Perennial allergic rhinitis
Journal
Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India
ISSN: 2231-3796
Titre abrégé: Indian J Otolaryngol Head Neck Surg
Pays: India
ID NLM: 9422551
Informations de publication
Date de publication:
Nov 2019
Nov 2019
Historique:
received:
15
06
2015
accepted:
16
09
2015
entrez:
26
11
2019
pubmed:
26
11
2019
medline:
26
11
2019
Statut:
ppublish
Résumé
To determine whether separate administration of Montelukast and Levocetirizine provide a better response in perennial allergic rhinitis (PAR) than their fixed dose combination. Total 151 patients underwent a hospital based clinical study, being divided in 3 discrete groups. One group was given non-bilayered combination of Montelukast and Levocetrizine, 2nd group was given their bilayered counterpart whereas 3rd group was given the drugs at 12 h interval. Medications were continued for 3 months before stoppage. All patients were followed up for 1 month more to note recurrence of symptoms of PAR on weekly basis. While the combination formulation gave 9.8 and 12.6 % symptom-free patients; separate administration of the molecules gave 43.3 % positive (symptom-free 1 month) result. Fixed-dose combination is found to cause 1.4 times more chance of recurrence. Though per se, Montelukast and Levocetrizine does not give excellent response in PAR, their separate administration provides better outcome. So a morning dose of Montelukast and Levocetirizine at bed time is recommended while treating PAR.
Identifiants
pubmed: 31763222
doi: 10.1007/s12070-015-0910-z
pii: 910
pmc: PMC6848620
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1674-1678Informations de copyright
© Association of Otolaryngologists of India 2015.
Déclaration de conflit d'intérêts
Conflict of interestNone.
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