Acetylation changes tau interactome to degrade tau in Alzheimer's disease animal and organoid models.
Alzheimer's disease
neurodegenerative diseases
tau
tau interactome
tau post-translational modification
Journal
Aging cell
ISSN: 1474-9726
Titre abrégé: Aging Cell
Pays: England
ID NLM: 101130839
Informations de publication
Date de publication:
01 2020
01 2020
Historique:
received:
20
03
2019
revised:
26
08
2019
accepted:
06
10
2019
pubmed:
26
11
2019
medline:
14
1
2021
entrez:
26
11
2019
Statut:
ppublish
Résumé
Alzheimer's disease (AD) is an age-related neurodegenerative disease. The most common pathological hallmarks are amyloid plaques and neurofibrillary tangles in the brain. In the brains of patients with AD, pathological tau is abnormally accumulated causing neuronal loss, synaptic dysfunction, and cognitive decline. We found a histone deacetylase 6 (HDAC6) inhibitor, CKD-504, changed the tau interactome dramatically to degrade pathological tau not only in AD animal model (ADLP
Identifiants
pubmed: 31763743
doi: 10.1111/acel.13081
pmc: PMC6974726
doi:
Substances chimiques
tau Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e13081Subventions
Organisme : Institute for Basic Science
ID : IBS-R013-A1
Pays : International
Organisme : National Research Foundation of Korea
ID : 2018R1A2A1A19019062
Pays : International
Organisme : National Research Foundation of Korea
ID : 2018R1A5A2025964
Pays : International
Organisme : Korea Health Industry Development Institute
ID : HI18C0630
Pays : International
Organisme : Chong Kun Dang Pharmaceutical Corp
Pays : International
Organisme : Ministry of Health & Welfare
Pays : International
Informations de copyright
© 2019 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd.
Références
Science. 2010 Oct 8;330(6001):198
pubmed: 20829454
Mol Cell. 2014 May 8;54(3):392-406
pubmed: 24703950
J Neurochem. 2008 Sep;106(5):2119-30
pubmed: 18636984
Biomed Res Int. 2014;2014:239164
pubmed: 25147790
J Alzheimers Dis. 2014;41(4):1193-205
pubmed: 24844691
Front Neurol. 2013 Jul 19;4:102
pubmed: 23882258
Brain. 2012 Mar;135(Pt 3):807-18
pubmed: 22366796
Nat Commun. 2014 Dec 08;5:5659
pubmed: 25482515
Cell Rep. 2017 Aug 29;20(9):2169-2183
pubmed: 28854366
Front Aging Neurosci. 2017 Apr 04;9:83
pubmed: 28420982
Science. 2007 May 4;316(5825):750-4
pubmed: 17478722
J Biol Chem. 2017 Sep 15;292(37):15277-15286
pubmed: 28760828
Mol Neurodegener. 2018 Jan 16;13(1):2
pubmed: 29338754
Alzheimers Dement (N Y). 2017 May 24;3(3):367-384
pubmed: 29067343
Curr Biol. 2018 Jul 9;28(13):2181-2189.e4
pubmed: 30008334
Alzheimers Dement (N Y). 2018 May 03;4:195-214
pubmed: 29955663
Biochem Biophys Res Commun. 2018 Sep 3;503(1):285-290
pubmed: 29890133
J Biol Chem. 2004 Feb 6;279(6):4869-76
pubmed: 14612456
Prog Neurobiol. 2013 Jun;105:49-59
pubmed: 23528736
Lancet. 2017 Nov 25;390(10110):2327-2329
pubmed: 29185425
N Engl J Med. 2010 Jan 28;362(4):329-44
pubmed: 20107219
Nat Rev Neurosci. 2016 Jan;17(1):5-21
pubmed: 26631930
Hum Mol Genet. 2014 Jan 1;23(1):104-16
pubmed: 23962722
Mol Cell Biol. 2008 Mar;28(5):1688-701
pubmed: 18180281
FEBS J. 2013 Feb;280(3):775-93
pubmed: 23181831
Cell Death Dis. 2018 May 29;9(6):655
pubmed: 29844403
Sci Transl Med. 2016 May 11;8(338):338ra66
pubmed: 27169802
Curr Alzheimer Res. 2018 Feb 22;15(4):313-335
pubmed: 28474569
Nat Med. 2015 Oct;21(10):1154-62
pubmed: 26390242
Aging Cell. 2020 Jan;19(1):e13081
pubmed: 31763743
J Neurosci Res. 2008 Sep;86(12):2763-73
pubmed: 18500754
Mol Neurodegener. 2016 Jun 29;11(1):47
pubmed: 27356871
Neuron. 2016 Apr 20;90(2):245-60
pubmed: 27041503