Novel genetic loci affecting facial shape variation in humans.
Adolescent
Adult
Anatomic Landmarks
Body Patterning
/ genetics
Child
Child, Preschool
Face
/ anatomy & histology
Female
Gene Expression Regulation, Developmental
/ genetics
Gene Ontology
Genetic Loci
/ genetics
Genetic Variation
Genome-Wide Association Study
Genotype
Humans
Imaging, Three-Dimensional
Male
Maxillofacial Development
/ genetics
Middle Aged
Multifactorial Inheritance
Phenotype
Polymorphism, Single Nucleotide
Young Adult
European
GWAS
face
gene regulation
genetics
genome-wide association study
genomics
human
images
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
26 11 2019
26 11 2019
Historique:
received:
03
07
2019
accepted:
22
11
2019
pubmed:
26
11
2019
medline:
12
5
2020
entrez:
26
11
2019
Statut:
epublish
Résumé
The human face represents a combined set of highly heritable phenotypes, but knowledge on its genetic architecture remains limited, despite the relevance for various fields. A series of genome-wide association studies on 78 facial shape phenotypes quantified from 3-dimensional facial images of 10,115 Europeans identified 24 genetic loci reaching study-wide suggestive association (p < 5 × 10
Identifiants
pubmed: 31763980
doi: 10.7554/eLife.49898
pii: 49898
pmc: PMC6905649
doi:
pii:
Banques de données
figshare
['10.6084/m9.figshare.10298396']
Types de publication
Journal Article
Meta-Analysis
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIDCR NIH HHS
ID : R01-DE027023
Pays : United States
Organisme : NIDCR NIH HHS
ID : U01 DE020078
Pays : United States
Organisme : NIDCR NIH HHS
ID : R01-DE016148
Pays : United States
Organisme : NIDCR NIH HHS
ID : R01 DE016148
Pays : United States
Organisme : Medical Research Council
ID : 102215/2/13/2
Pays : United Kingdom
Organisme : NIDCR NIH HHS
ID : U01-DE020078
Pays : United States
Organisme : Medical Research Council
ID : G9815508
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : NIDCR NIH HHS
ID : X01-HG007821
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201200008I
Pays : United States
Organisme : NCBDD CDC HHS
ID : R01 DD000295
Pays : United States
Organisme : Medical Research Council
ID : MC_PC_19009
Pays : United Kingdom
Organisme : NIDCR NIH HHS
ID : R01 DE027023
Pays : United States
Organisme : Medical Research Council
ID : MC_UU_00011/1
Pays : United Kingdom
Organisme : NIDCR NIH HHS
ID : U01-DE20078
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201200008C
Pays : United States
Organisme : Medical Research Council
ID : MC_PC_15018
Pays : United Kingdom
Investigateurs
None On Behalf Of The International Visible Trait Genetics VisiGen Consortium
Informations de copyright
© 2019, Xiong et al.
Déclaration de conflit d'intérêts
ZX, GD, LH, ML, PH, Md, GZ, KA, DL, YL, BP, EF, MM, JS, KM, SX, LJ, SW, Fd, BL, SR, AZ, SL, GS, LP, HT, RG, MB, SC, CG, GP, GB, FR, AU, MI, EW, SK, TN, RP, SB, SM, KT, AR, NM, TS, ES, SW, FL, MK No competing interests declared
Références
Nat Genet. 2018 Nov;50(11):1593-1599
pubmed: 30349118
Nat Genet. 2014 Nov;46(11):1173-86
pubmed: 25282103
J Pediatr. 2009 Dec;155(6):909-13
pubmed: 19656524
Am J Med Genet A. 2011 Feb;155A(2):270-9
pubmed: 21271641
Nature. 2012 Sep 6;489(7414):57-74
pubmed: 22955616
Sci Rep. 2018 Jan 8;8(1):12
pubmed: 29311563
Hum Genet. 2013 Oct;132(10):1187-91
pubmed: 23793515
Bioinformatics. 2010 Sep 15;26(18):2336-7
pubmed: 20634204
Bioinformatics. 2014 Oct;30(19):2828-9
pubmed: 24894501
Cytometry A. 2013 Jan;83(1):38-47
pubmed: 22837061
Genome Res. 2012 Mar;22(3):446-55
pubmed: 22234890
Eur J Med Genet. 2011 May-Jun;54(3):301-5
pubmed: 21199695
Cell. 1999 Mar 5;96(5):737-49
pubmed: 10089888
Hum Mol Genet. 2015 May 1;24(9):2649-61
pubmed: 25631878
Epigenomics. 2012 Jun;4(3):317-24
pubmed: 22690667
Nature. 2012 Nov 1;491(7422):56-65
pubmed: 23128226
Biochim Biophys Acta Mol Basis Dis. 2018 Mar;1864(3):843-850
pubmed: 29203346
Nat Genet. 2018 May;50(5):652-656
pubmed: 29662168
Orthod Craniofac Res. 2004 Nov;7(4):198-204
pubmed: 15562582
Nat Commun. 2018 May 8;9(1):1684
pubmed: 29739929
Nat Genet. 2007 Jul;39(7):875-81
pubmed: 17558409
BMC Genomics. 2018 Jun 19;19(1):481
pubmed: 29921221
Nat Commun. 2017 Feb 24;8:14364
pubmed: 28232668
Nat Rev Genet. 2007 Mar;8(3):206-16
pubmed: 17304246
Nat Rev Genet. 2009 Sep;10(9):639-50
pubmed: 19687804
Orthod Craniofac Res. 2009 Feb;12(1):33-42
pubmed: 19154273
PLoS Genet. 2014 Sep 25;10(9):e1004572
pubmed: 25254375
OMICS. 2012 May;16(5):284-7
pubmed: 22455463
Am J Phys Anthropol. 2011 Aug;145(4):599-614
pubmed: 21660932
Am J Hum Genet. 2008 Feb;82(2):411-23
pubmed: 18252221
Genome Res. 2005 Aug;15(8):1034-50
pubmed: 16024819
Nat Commun. 2016 May 19;7:11616
pubmed: 27193062
Nat Genet. 2010 Jan;42(1):24-6
pubmed: 20023658
Heredity (Edinb). 2005 Sep;95(3):221-7
pubmed: 16077740
Nat Genet. 2018 Mar;50(3):414-423
pubmed: 29459680
Genet Epidemiol. 2011 Sep;35(6):469-78
pubmed: 21618603
BMC Bioinformatics. 2013 Jul 22;14:232
pubmed: 23870191
J Med Genet. 2017 Jun;54(6):371-380
pubmed: 28289185
Nat Biotechnol. 2007 Dec;25(12):1468-75
pubmed: 18037878
Nat Genet. 2011 Jun;43(6):561-4
pubmed: 21572415
Int J Epidemiol. 2013 Feb;42(1):111-27
pubmed: 22507743
Dev Biol. 2012 Jun 1;366(1):2-9
pubmed: 22230617
PLoS Biol. 2006 Mar;4(3):e72
pubmed: 16494531
PLoS One. 2017 Apr 25;12(4):e0176566
pubmed: 28441456
Mech Dev. 2005 Feb;122(2):131-44
pubmed: 15652702
Nat Genet. 2012 Jun 17;44(7):821-4
pubmed: 22706312
PLoS Genet. 2009 Jun;5(6):e1000529
pubmed: 19543373
Nat Genet. 2016 Jul;48(7):709-17
pubmed: 27182965
Nat Commun. 2015 Jun 24;6:7500
pubmed: 26105758
PLoS Genet. 2014 Apr 17;10(4):e1004234
pubmed: 24743097
Genesis. 2008 Feb;46(2):92-103
pubmed: 18257070
Nature. 2002 Oct 24;419(6909):832-7
pubmed: 12397357
Nat Genet. 2012 Sep;44(9):968-71
pubmed: 22863734
Am J Hum Genet. 2012 Mar 9;90(3):478-85
pubmed: 22341974
Hum Mol Genet. 2017 Feb 15;26(4):829-842
pubmed: 28087736
Nat Genet. 2009 Apr;41(4):473-7
pubmed: 19270707
PLoS Genet. 2012 Sep;8(9):e1002932
pubmed: 23028347
Nat Genet. 1997 Jul;16(3):311-5
pubmed: 9207801
Am J Hum Genet. 2011 Jan 7;88(1):76-82
pubmed: 21167468
Mol Psychiatry. 2018 May;23(5):1336-1344
pubmed: 28416807
Nat Genet. 1993 Mar;3(3):241-6
pubmed: 8387379
Int J Epidemiol. 2013 Feb;42(1):97-110
pubmed: 22507742
Dev Cell. 2015 Apr 6;33(1):56-66
pubmed: 25800090
Nat Genet. 2013 Jun;45(6):580-5
pubmed: 23715323
PLoS Genet. 2016 Aug 25;12(8):e1006149
pubmed: 27560520
Eur J Epidemiol. 2013 Nov;28(11):889-926
pubmed: 24258680
Dev Biol. 2010 Mar 15;339(2):418-28
pubmed: 20067783
Dev Biol. 2008 Sep 1;321(1):273-82
pubmed: 18634775
Hum Genet. 2017 Mar;136(3):275-286
pubmed: 28054174
Database (Oxford). 2016 Jun 23;2016:
pubmed: 27337980
Hum Mol Genet. 2014 Nov 1;23(21):5750-62
pubmed: 24916375
Nat Methods. 2014 Apr;11(4):407-9
pubmed: 24531419
Nat Genet. 2010 Jun;42(6):525-9
pubmed: 20436469
J Genet Genomics. 2018 Aug 20;45(8):419-432
pubmed: 30174134
Paediatr Perinat Epidemiol. 2001 Jan;15(1):74-87
pubmed: 11237119
Nature. 2015 Oct 1;526(7571):68-74
pubmed: 26432245
Nature. 2010 Oct 14;467(7317):832-8
pubmed: 20881960
Am J Hum Genet. 2007 Sep;81(3):559-75
pubmed: 17701901
Am J Hum Genet. 2009 Oct;85(4):528-35
pubmed: 19804850
Cleft Palate Craniofac J. 2016 Nov;53(6):e185-e197
pubmed: 26492185
Cell. 2013 Feb 14;152(4):691-702
pubmed: 23415220
IEEE Trans Image Process. 2016 Feb;25(2):580-8
pubmed: 26540684
PLoS Genet. 2016 Aug 25;12(8):e1006174
pubmed: 27560698
Hum Mol Genet. 2010 Mar 1;19(5):774-89
pubmed: 20007998
Dev Dyn. 2004 Feb;229(2):400-10
pubmed: 14745966
Nat Commun. 2015 Mar 16;6:6414
pubmed: 25775280
PLoS One. 2016 Sep 01;11(9):e0162250
pubmed: 27584156
Cell. 2015 Sep 24;163(1):68-83
pubmed: 26365491
Dev Dyn. 2014 Dec;243(12):1646-57
pubmed: 25283277
Nucleic Acids Res. 2014 Jan;42(Database issue):D1001-6
pubmed: 24316577
Nat Methods. 2011 Dec 04;9(2):179-81
pubmed: 22138821
Science. 2016 Nov 11;354(6313):760-764
pubmed: 27738015
Cell. 2008 Jul 11;134(1):25-36
pubmed: 18614008
Am J Phys Anthropol. 1954 Dec;12(4):615-8
pubmed: 14350081