Evaluation of Peripapillary Choroidal Microvasculature to Detect Glaucomatous Damage in Eyes With High Myopia.
Adult
Aged
Aged, 80 and over
Choroid
/ blood supply
Choroid Diseases
/ diagnosis
Ciliary Arteries
/ pathology
Cross-Sectional Studies
Female
Fluorescein Angiography
Glaucoma, Open-Angle
/ diagnosis
Humans
Intraocular Pressure
/ physiology
Male
Microvessels
Middle Aged
Myopia, Degenerative
/ diagnosis
Nerve Fibers
/ pathology
Retinal Ganglion Cells
/ pathology
Tomography, Optical Coherence
Visual Field Tests
Visual Fields
/ physiology
Young Adult
Journal
Journal of glaucoma
ISSN: 1536-481X
Titre abrégé: J Glaucoma
Pays: United States
ID NLM: 9300903
Informations de publication
Date de publication:
01 2020
01 2020
Historique:
pubmed:
26
11
2019
medline:
15
8
2020
entrez:
26
11
2019
Statut:
ppublish
Résumé
Parapapillary choroidal microvasculature dropout (MvD), as observed by optical coherence tomography (OCT) angiography, was useful to detect glaucomatous damage in highly myopic eyes with unreliable OCT results due to segmentation errors. The purpose of this study was to evaluate the usefulness of optical coherence tomography angiography (OCTA) imaging of the peripapillary choroidal microvasculature in detecting glaucomatous damage in highly myopic eyes, in cases where evaluating the thickness of the retinal nerve fiber layer (RNFL) is unreliable due to OCT segmentation errors. Forty-five highly myopic eyes with primary open-angle glaucoma (POAG) with an axial length >26.5 mm, and 15 age-matched and axial length-matched 15 control eyes were included in this cross-sectional observational study. All participants had a segmentation error in OCT circumpapillary RNFL scanning. The peripapillary choroidal microvasculature was evaluated on en-face images obtained using swept-source OCTA. MvD was defined as a focal sectoral capillary dropout with no visible microvascular network identified in the choroidal layer. The topographic correlation between the MvD and a hemifield visual field (VF) defect was assessed using κ statistics. The MvD size was assessed by measuring both its area and circumferential extent. Choroidal MvD was observed in 44 of the 45 (97.8%) POAG eyes with high myopia, while none of the control eyes showed a choroidal MvD. There was an excellent topographic relationship between the choroidal MvD and the hemifield VF defect (κ=0.863, P<0.001). The area (R=0.2619, P=0.0006) and circumferential extent (R=0.3088, P=0.0002) of the MvD have significantly associated with the VF mean deviation. Choroidal MvDs were observed in most of the highly myopic POAG eyes and were topographically correlated with the location of glaucomatous VF defects despite unreliable OCT RNFL thickness measurements. Using OCTA to investigate the choroidal microvasculature may facilitate diagnoses of glaucoma in highly myopic eyes.
Identifiants
pubmed: 31764577
doi: 10.1097/IJG.0000000000001408
pii: 00061198-202001000-00006
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
39-45Commentaires et corrections
Type : CommentIn
Type : CommentIn
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