Firefighter's Acute Inflammatory Response to Wildfire Suppression.
Journal
Journal of occupational and environmental medicine
ISSN: 1536-5948
Titre abrégé: J Occup Environ Med
Pays: United States
ID NLM: 9504688
Informations de publication
Date de publication:
02 2020
02 2020
Historique:
pubmed:
26
11
2019
medline:
7
4
2021
entrez:
26
11
2019
Statut:
ppublish
Résumé
The purpose of this study was to determine the inflammatory response to a 12-hour wildfire suppression shift, in firefighters attending the "Black Saturday" natural disaster. Thirty-eight male volunteer firefighters provided venous blood samples before and after a 12-hour firefighting shift. Pre- to post-shift changes in pro-inflammatory (Interleukin [IL]-1β, IL-2, IL-6, IL-8, IL-12P70, granulocyte macrophage-colony stimulating factor [GM-CSF], tumor necrosis factor-alpha [TNF-α], interferon-gamma [IFNγ]), and anti-inflammatory (IL-4, IL-5, IL-7, IL-10, IL-13) cytokines were measured with paired sample t tests, or Wilcoxon t tests for non-parametric data. Interleukin (IL)-6 (P = 0.003) and IL-8 (P = 0.017) were significantly increased following 12-hours of wildfire suppression. There was also a significant decrease in IL-10 (P = 0.021). The observed acute inflammatory response may have resulted from multiple stressors including physical exertion, thermal strain, or smoke inhalation experienced during the shift, and may be a necessary response for the body to adapt to stressor exposure.
Identifiants
pubmed: 31764604
doi: 10.1097/JOM.0000000000001775
pii: 00043764-202002000-00008
doi:
Substances chimiques
Cytokines
0
IL10 protein, human
0
IL1B protein, human
0
Interleukin-1beta
0
Tumor Necrosis Factor-alpha
0
Interleukin-10
130068-27-8
Interferon-gamma
82115-62-6
Granulocyte-Macrophage Colony-Stimulating Factor
83869-56-1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
145-148Références
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