Miniaturized Intracavitary Forward-Looking Ultrasound Transducer for Tissue Ablation.
Journal
IEEE transactions on bio-medical engineering
ISSN: 1558-2531
Titre abrégé: IEEE Trans Biomed Eng
Pays: United States
ID NLM: 0012737
Informations de publication
Date de publication:
07 2020
07 2020
Historique:
pubmed:
26
11
2019
medline:
25
6
2021
entrez:
26
11
2019
Statut:
ppublish
Résumé
This paper aims to develop a miniaturized forward-looking ultrasound transducer for intracavitary tissue ablation, which can be used through an endoscopic device. The internal ultrasound (US) delivery is capable of directly interacting with the target tumor, resolving adverse issues of currently available US devices, such as unintended tissue damage and insufficient delivery of acoustic power. To transmit a high acoustic pressure from a small aperture (<3 mm), a double layer transducer (1.3 MHz) was designed and fabricated based on numerical simulations. The electric impedance and the acoustic pressure of the actual device was characterized with an impedance analyzer and a hydrophone. Ex vivo tissue ablation tests and temperature monitoring were then conducted with porcine livers. The acoustic intensity of the transducer was 37.1 W/cm This miniaturized US transducer is a promising medical option for the precise tissue ablation, which can reduce the risk of unintended tissue damage found in noninvasive US treatments. Having a small aperture (2 mm), the intracavitary device is capable of ablating a bio tissue in 5 min with a relatively low electric power (<17 W).
Identifiants
pubmed: 31765299
doi: 10.1109/TBME.2019.2954524
pmc: PMC7269183
mid: NIHMS1594624
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2084-2093Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL141967
Pays : United States
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