Specificity of gut microbiota in children with autism spectrum disorder in Slovakia and its correlation with astrocytes activity marker and specific behavioural patterns.
Astrocytes
/ metabolism
Autism Spectrum Disorder
/ diagnosis
Biomarkers
/ blood
Case-Control Studies
Chemokine CCL4
/ blood
Chemokine CXCL10
/ blood
Child
Child, Preschool
Feces
/ chemistry
Gastrointestinal Microbiome
/ physiology
Humans
Leukocyte L1 Antigen Complex
/ analysis
Male
S100 Calcium Binding Protein beta Subunit
/ blood
Slovakia
ASD
Gut microbiota
MIP-1β
S100B
Journal
Physiology & behavior
ISSN: 1873-507X
Titre abrégé: Physiol Behav
Pays: United States
ID NLM: 0151504
Informations de publication
Date de publication:
01 02 2020
01 02 2020
Historique:
received:
14
08
2019
revised:
04
11
2019
accepted:
21
11
2019
pubmed:
26
11
2019
medline:
23
1
2021
entrez:
26
11
2019
Statut:
ppublish
Résumé
Recent research suggests the involvement of bidirectional gut-brain axis in autism spectrum disorder (ASD). The aim of this study was to establish the role of changed gut microbiota in behavioural and gastrointestinal manifestations, but also in astrocyte activation in children with ASD. Distinct faecal microbiota in children with ASD was found to be more heterogeneous compared to that in neurotypical children. Different bacterial abundance and correlation with behavioural and GI manifestations revealed several bacterial genera possibly important for ASD. Microbial-neuronal cross talk could be accomplished through S100B, released by glial cells, activated by low grade inflammation. More complex studies are required to understand ASD pathogenesis.
Identifiants
pubmed: 31765662
pii: S0031-9384(19)30866-2
doi: 10.1016/j.physbeh.2019.112745
pii:
doi:
Substances chimiques
Biomarkers
0
CXCL10 protein, human
0
Chemokine CCL4
0
Chemokine CXCL10
0
Leukocyte L1 Antigen Complex
0
S100 Calcium Binding Protein beta Subunit
0
S100B protein, human
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
112745Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.