Metabolic aspects of cardiovascular diseases: Is FoxO1 a player or a target?
Cardiovascular
FoxO1
Type 2 diabetes
Journal
The international journal of biochemistry & cell biology
ISSN: 1878-5875
Titre abrégé: Int J Biochem Cell Biol
Pays: Netherlands
ID NLM: 9508482
Informations de publication
Date de publication:
01 2020
01 2020
Historique:
received:
14
10
2019
revised:
14
11
2019
accepted:
21
11
2019
pubmed:
26
11
2019
medline:
6
10
2020
entrez:
26
11
2019
Statut:
ppublish
Résumé
The O subfamily of forkhead (FoxO) 1 is a crucial regulator of cell metabolism in several tissues, including the heart, where it is involved in cardiac regulation of glucose and lipid metabolic pathways, and endothelium, controlling the levels of some relevant biomarkers in atherosclerotic process. Despite the growing understanding of FoxO1 biology, the metabolic consequences of FoxO1 modifications and its implication in CVD, atherosclerosis and T2DM are still not incompletely described. In this review we discuss how FoxO1 affects cardiovascular pathophysiology and which of its effects should be restrained or enhanced to preserve endothelial and heart functions.
Identifiants
pubmed: 31765819
pii: S1357-2725(19)30236-5
doi: 10.1016/j.biocel.2019.105659
pii:
doi:
Substances chimiques
FOXO1 protein, human
0
Forkhead Box Protein O1
0
Glucose
IY9XDZ35W2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
105659Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.