Dopamine D3 receptor: A neglected participant in Parkinson Disease pathogenesis and treatment?
BDNF
Dopamine D3 receptor
Neuroinflammation
Parkinson disease
α-Synuclein
Journal
Ageing research reviews
ISSN: 1872-9649
Titre abrégé: Ageing Res Rev
Pays: England
ID NLM: 101128963
Informations de publication
Date de publication:
01 2020
01 2020
Historique:
received:
18
10
2019
revised:
13
11
2019
accepted:
20
11
2019
pubmed:
26
11
2019
medline:
1
7
2020
entrez:
26
11
2019
Statut:
ppublish
Résumé
Parkinson disease (PD) is a neurodegenerative disorder characterized by motor and non-motor symptoms which relentlessly and progressively lead to substantial disability and economic burden. Pathologically, these symptoms follow the loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc) associated with abnormal α-synuclein (α-Syn) deposition as cytoplasmic inclusions called Lewy bodies in pigmented brainstem nuclei, and in dystrophic neurons in striatal and cortical regions (Lewy neurites). Pharmacotherapy for PD focuses on improving quality of life and primarily targets dopaminergic pathways. Dopamine acts through two families of receptors, dopamine D1-like and dopamine D2-like; dopamine D3 receptors (D3R) belong to dopamine D2 receptor (D2R) family. Although D3R's precise role in the pathophysiology and treatment of PD has not been determined, we present evidence suggesting an important role for D3R in the early development and occurrence of PD. Agonist activation of D3R increases dopamine concentration, decreases α-Syn accumulation, enhances secretion of brain derived neurotrophic factors (BDNF), ameliorates neuroinflammation, alleviates oxidative stress, promotes neurogenesis in the nigrostriatal pathway, interacts with D1R to reduce PD associated motor symptoms and ameliorates side effects of levodopa (L-DOPA) treatment. Furthermore, D3R mutations can predict PD age of onset and prognosis of PD treatment. The role of D3R in PD merits further research. This review elucidates the potential role of D3R in PD pathogenesis and therapy.
Identifiants
pubmed: 31765822
pii: S1568-1637(19)30380-0
doi: 10.1016/j.arr.2019.100994
pmc: PMC6939386
mid: NIHMS1545217
pii:
doi:
Substances chimiques
Receptors, Dopamine D3
0
alpha-Synuclein
0
Dopamine
VTD58H1Z2X
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
100994Subventions
Organisme : NIA NIH HHS
ID : P30 AG066444
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS107281
Pays : United States
Organisme : NIA NIH HHS
ID : P01 AG026276
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS075321
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS103957
Pays : United States
Organisme : NINDS NIH HHS
ID : R03 NS090214
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS058714
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS092865
Pays : United States
Organisme : NIA NIH HHS
ID : P01 AG003991
Pays : United States
Organisme : NIA NIH HHS
ID : P50 AG005681
Pays : United States
Informations de copyright
Copyright © 2019 The Authors. Published by Elsevier B.V. All rights reserved.
Références
Neurotox Res. 2013 Nov;24(4):523-31
pubmed: 23820985
Exp Neurol. 2012 Oct;237(2):355-62
pubmed: 22836146
J Pharmacol Exp Ther. 1998 Oct;287(1):187-97
pubmed: 9765337
Biochim Biophys Acta. 2007 Apr;1768(4):871-87
pubmed: 17274946
Int Clin Psychopharmacol. 1997 Jul;12 Suppl 3:S7-14
pubmed: 9347387
Eur J Pharmacol. 1988 Mar 1;147(2):249-58
pubmed: 3130270
Behav Brain Res. 2014 Nov 1;274:186-93
pubmed: 25110304
Exp Neurol. 2004 Nov;190(1):157-70
pubmed: 15473989
J Neurophysiol. 2016 Jan 1;115(1):363-9
pubmed: 26561599
Expert Opin Drug Discov. 2016 Jul;11(7):641-64
pubmed: 27135354
Brain Res. 2002 Nov 15;955(1-2):138-52
pubmed: 12419530
Int J Neuropsychopharmacol. 2014 Dec;17(12):1981-93
pubmed: 24852388
Ment Health Clin. 2016 Aug 31;6(5):229-235
pubmed: 29955475
Mov Disord. 2015 Feb;30(2):160-6
pubmed: 25641350
J Neurosci. 2006 Feb 1;26(5):1457-64
pubmed: 16452669
J Med Chem. 2018 Apr 26;61(8):3712-3725
pubmed: 29589445
Neurobiol Dis. 2015 Feb;74:325-35
pubmed: 25511804
Brain Res. 2007 Jul 30;1160:113-23
pubmed: 17573046
Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6809-14
pubmed: 10829080
J Biol Chem. 2008 Sep 19;283(38):26016-25
pubmed: 18644790
Nature. 1990 Sep 13;347(6289):146-51
pubmed: 1975644
EMBO J. 1989 Dec 20;8(13):4025-34
pubmed: 2531656
Front Neurosci. 2016 Mar 11;10:77
pubmed: 27013940
Neuropsychopharmacology. 1999 Jan;20(1):60-80
pubmed: 9885786
Life Sci. 1999;64(11):939-51
pubmed: 10201643
Behav Brain Res. 2007 Aug 22;182(1):1-11
pubmed: 17570538
Biomed Rep. 2014 Mar;2(2):275-281
pubmed: 24649110
Mol Neurobiol. 2019 May;56(5):3437-3450
pubmed: 30128652
Acta Pharmacol Sin. 2016 Mar;37(3):322-33
pubmed: 26775662
Front Pharmacol. 2014 Jul 10;5:161
pubmed: 25071579
Learn Mem. 2006 Mar-Apr;13(2):161-7
pubmed: 16585791
Neurology. 2004 May 25;62(10):1835-8
pubmed: 15159488
Autophagy. 2016 Dec;12(12):2374-2385
pubmed: 27754761
Mol Pharmacol. 2016 Apr;89(4):457-66
pubmed: 26843180
Acta Pharm Sin B. 2017 Nov;7(6):611-622
pubmed: 29159020
Brain Res. 2007 Feb 2;1131(1):187-96
pubmed: 17182012
PLoS One. 2012;7(11):e49483
pubmed: 23185343
Acta Pharmacol Sin. 2017 Oct;38(10):1317-1328
pubmed: 28649132
Ann Neurol. 2011 Jun;69(6):986-96
pubmed: 21416496
FASEB J. 2004 Oct;18(13):1600-2
pubmed: 15319371
Neurosci Lett. 2000 Mar 10;281(2-3):167-70
pubmed: 10704769
Neuropharmacology. 2017 Feb;113(Pt A):110-123
pubmed: 27693549
ACS Chem Neurosci. 2014 Aug 20;5(8):700-17
pubmed: 24960209
Neurosci Lett. 2008 Aug 1;440(2):97-102
pubmed: 18555604
Psychogeriatrics. 2013 Sep;13(3):189-95
pubmed: 25913769
J Exp Neurosci. 2018 May 31;12:1179069518779829
pubmed: 29899667
Prog Neuropsychopharmacol Biol Psychiatry. 2019 Jan 10;88:168-174
pubmed: 30017781
Neuroscience. 2016 Sep 7;331:158-68
pubmed: 27339729
Brain. 2013 Aug;136(Pt 8):2419-31
pubmed: 23884810
J Neurochem. 2019 Sep;150(5):626-636
pubmed: 31265130
J Auton Pharmacol. 1990;10 Suppl 1:s53-60
pubmed: 1983009
Eur J Pharmacol. 2004 Nov 3;504(1-2):27-32
pubmed: 15507217
Oncotarget. 2017 Jan 31;8(5):7224-7225
pubmed: 28086229
Neuropharmacology. 2018 May 1;133:216-223
pubmed: 29407766
Psychopharmacology (Berl). 2008 Oct;200(3):403-11
pubmed: 18607572
J Pharmacol Exp Ther. 1999 Apr;289(1):202-10
pubmed: 10087005
Cell Mol Life Sci. 2010 Jun;67(12):1971-86
pubmed: 20165900
Mov Disord. 2003 Sep;18 Suppl 6:S80-7
pubmed: 14502660
J Neurosci. 2010 Dec 8;30(49):16453-8
pubmed: 21147984
Neuroscience. 2013 Sep 17;248:112-26
pubmed: 23732230
Mol Biol Rep. 2014 May;41(5):2929-36
pubmed: 24452723
Neuropharmacology. 2011 Feb-Mar;60(2-3):284-94
pubmed: 20850462
Arch Neurol. 2001 May;58(5):835
pubmed: 11346387
Exp Neurol. 2009 Oct;219(2):543-52
pubmed: 19619535
Neuroscience. 2005;136(2):381-6
pubmed: 16216425
Biochem Soc Trans. 2018 Aug 20;46(4):891-909
pubmed: 30026371
J Cent Nerv Syst Dis. 2017 Aug 16;9:1179573517726335
pubmed: 28855798
Neuroreport. 2011 Jul 13;22(10):489-93
pubmed: 21642879
Prog Brain Res. 2014;211:255-75
pubmed: 24968784
Physiol Behav. 2015 Aug 1;147:193-7
pubmed: 25914172
Naunyn Schmiedebergs Arch Pharmacol. 2013 Feb;386(2):155-66
pubmed: 23128852
Neurology. 2011 Aug 23;77(8):767-74
pubmed: 21832216
Sci Rep. 2017 Jan 30;7:41589
pubmed: 28134302
Synapse. 2015 Dec;69(12):577-91
pubmed: 26422464
Eur Neuropsychopharmacol. 2019 Jan;29(1):127-136
pubmed: 30470662
J Neural Transm Gen Sect. 1994;95(1):71-4
pubmed: 7857588
Ann N Y Acad Sci. 2014 Nov;1329:45-66
pubmed: 25145951
Mol Psychiatry. 2000 Jul;5(4):378-88
pubmed: 10889548
J Neurophysiol. 2011 May;105(5):2260-74
pubmed: 21389298
Parkinsonism Relat Disord. 2011 May;17(4):260-4
pubmed: 21310646
Parkinsons Dis. 2012;2012:591094
pubmed: 22191072
Parkinsonism Relat Disord. 2016 Jan;22:102-5
pubmed: 26627941
Pharmacol Rev. 2011 Mar;63(1):182-217
pubmed: 21303898
Proc Natl Acad Sci U S A. 2005 Mar 1;102(9):3513-8
pubmed: 15716360
Bioorg Med Chem. 2016 Nov 1;24(21):5088-5102
pubmed: 27591013
Neurosci Lett. 2015 Jan 12;585:33-7
pubmed: 25445374
Int Immunopharmacol. 2016 Jul;36:187-198
pubmed: 27156126
Neuropharmacology. 2001 Jul;41(1):62-71
pubmed: 11445186
Synapse. 2010 Jun;64(6):449-59
pubmed: 20175227
Eur J Neurosci. 2005 Nov;22(10):2422-30
pubmed: 16307585
Pharmacol Biochem Behav. 2010 Jun;95(4):473-8
pubmed: 20385162
J Biol Chem. 2000 Dec 8;275(49):38944-8
pubmed: 11007776
J Neurosci. 1996 Dec 1;16(23):7776-82
pubmed: 8922433
CNS Drug Rev. 2003 Summer;9(2):141-58
pubmed: 12847556
Parkinsonism Relat Disord. 2010 Jul;16(6):381-3
pubmed: 20434388
Int J Neuropsychopharmacol. 2017 Oct 1;20(10):788-796
pubmed: 28531264
Brain Res. 2001 Jun 29;905(1-2):111-9
pubmed: 11423085
Neurosci Lett. 2013 Dec 17;557 Pt B:123-8
pubmed: 24157858
Arch Neurol. 2004 May;61(5):641-4
pubmed: 15148138
J Neural Transm (Vienna). 2000;107(10):1165-73
pubmed: 11129106
Neurobiol Dis. 2011 Jan;41(1):51-61
pubmed: 20736067
Curr Opin Psychiatry. 2013 Jan;26(1):120-3
pubmed: 23132284
Eur J Pharmacol. 2014 Jun 5;732:105-10
pubmed: 24685638
Exp Neurol. 2011 Dec;232(2):333-8
pubmed: 21963652
Parkinsonism Relat Disord. 2008;14 Suppl 2:S159-64
pubmed: 18638717
Synapse. 2015 Apr;69(4):183-9
pubmed: 25645960
J Neural Transm (Vienna). 2003 Apr;110(4):373-80
pubmed: 12658365
J Neurol Sci. 2017 Jan 15;372:433-438
pubmed: 27817855
Front Immunol. 2019 May 01;10:981
pubmed: 31118938
Neuropharmacology. 2013 Apr;67:370-8
pubmed: 23238327
Ann Neurol. 1997 Aug;42(2):215-21
pubmed: 9266732
J Neurol Sci. 1995 Oct;132(2):156-61
pubmed: 8543941
Cereb Cortex. 2017 Jan 1;27(1):435-446
pubmed: 26483399
J Pharmacol Exp Ther. 2002 Nov;303(2):791-804
pubmed: 12388666
Pol J Pharmacol. 2004 Sep-Oct;56(5):519-26
pubmed: 15591639
Eur J Pharmacol. 1999 Feb 5;366(2-3):293-300
pubmed: 10082211
J Neurol Neurosurg Psychiatry. 2016 Oct;87(10):1106-11
pubmed: 27076492
Proc Natl Acad Sci U S A. 1991 Oct 15;88(20):9175-9
pubmed: 1833775
Behav Pharmacol. 2012 Jun;23(3):280-91
pubmed: 22470105
Brain. 2009 May;132(Pt 5):1366-75
pubmed: 19153147
Eur Neuropsychopharmacol. 2013 Aug;23(8):799-813
pubmed: 23791072
Clin Ther. 2008 May;30(5):813-24
pubmed: 18555929
Drugs. 2014 Dec;74(18):2175-90
pubmed: 25385556
Neuropharmacology. 2011 May;60(6):892-900
pubmed: 21272591
Brain Res Brain Res Rev. 2004 Dec;47(1-3):126-44
pubmed: 15572168
Exp Neurol. 2004 Jul;188(1):128-38
pubmed: 15191809
ACS Chem Neurosci. 2017 Mar 15;8(3):486-500
pubmed: 27801563
Biol Psychiatry. 2008 Aug 1;64(3):235-40
pubmed: 18325483
J Neuroimmunol. 2015 Jul 15;284:18-29
pubmed: 26025054
Nature. 2001 May 3;411(6833):86-9
pubmed: 11333982
J Neurosci. 2016 Feb 3;36(5):1577-89
pubmed: 26843639
Lancet. 2015 Aug 29;386(9996):896-912
pubmed: 25904081
PLoS One. 2012;7(8):e42652
pubmed: 22880070
Exp Neurol. 2007 Apr;204(2):583-8
pubmed: 17258710
Front Neurosci. 2016 Oct 05;10:451
pubmed: 27761108
J Interferon Cytokine Res. 2005 Jul;25(7):395-406
pubmed: 16022584
Hum Genet. 2009 Jul;126(1):51-90
pubmed: 19506906
Neurol India. 2018 Mar-Apr;66(Supplement):S15-S25
pubmed: 29503324
Neuropharmacology. 2018 Aug;138:304-314
pubmed: 29936243
Parkinsonism Relat Disord. 2016 Sep;30:13-7
pubmed: 27325396
Folia Neuropathol. 2014;52(2):179-86
pubmed: 25118903
Arch Gen Psychiatry. 2006 Dec;63(12):1325-35
pubmed: 17146007
J Immunol. 2013 May 15;190(10):5048-56
pubmed: 23589621
Eur J Neurosci. 1998 Aug;10(8):2565-73
pubmed: 9767387
Curr Opin Neurobiol. 2018 Feb;48:71-78
pubmed: 29125979
Autophagy. 2015 Nov 2;11(11):2057-2073
pubmed: 26649942
Expert Rev Neurother. 2009 Oct;9(10):1547-65
pubmed: 19831843
J Pharmacol Exp Ther. 1995 Dec;275(3):1239-46
pubmed: 8531087
ChemMedChem. 2014 Dec;9(12):2653-60
pubmed: 25338762
Psychopharmacology (Berl). 2007 Oct;194(3):289-95
pubmed: 17579840
J Neurosci. 2000 Dec 1;20(23):8677-84
pubmed: 11102473
Neural Plast. 2018 Feb 4;2018:4196961
pubmed: 29531524
Transl Psychiatry. 2016 Mar 08;6:e753
pubmed: 26954980
Expert Opin Pharmacother. 2013 Jun;14(8):1077-86
pubmed: 23517091
J Mol Neurosci. 2013 Oct;51(2):573-80
pubmed: 23681749
Neuropharmacology. 2014 Apr;79:726-37
pubmed: 24333147
Eur J Pharmacol. 2014 Feb 5;724:31-42
pubmed: 24365490
Pharmacol Biochem Behav. 2009 Aug;93(2):141-7
pubmed: 19426754
Eur J Pharmacol. 1998 Jun 12;351(1):31-7
pubmed: 9698202
Intern Med. 2013;52(3):325-32
pubmed: 23370739
J Neurosci Res. 2010 Aug 15;88(11):2513-23
pubmed: 20623619
BMC Biol. 2004 Oct 11;2:22
pubmed: 15473914
Pharmacogenomics J. 2018 Jan;18(1):196-200
pubmed: 27779245
Eur J Pharmacol. 1994 Nov 24;265(3):175-7
pubmed: 7875234
Neurology. 2001 Nov 27;57(10):1829-34
pubmed: 11723272
Nature. 1991 Apr 18;350(6319):614-9
pubmed: 1826762
Int J Med Chem. 2011;2011:403039
pubmed: 25954517
Mol Psychiatry. 2010 Jun;15(6):560-73
pubmed: 20489735
Neuroscience. 2000;98(2):263-73
pubmed: 10854757
CNS Neurol Disord Drug Targets. 2006 Jun;5(3):345-53
pubmed: 16787233
Bioorg Med Chem. 2015 Jul 15;23(14):4000-12
pubmed: 25650314
J Alzheimers Dis. 2015;49(4):1179-87
pubmed: 26682692
Behav Pharmacol. 2008 Dec;19(8):786-95
pubmed: 19020413
Neuropharmacology. 2013 Aug;71:273-81
pubmed: 23602989
Eur J Neurosci. 2008 Oct;28(7):1231-40
pubmed: 18973551
Brain Struct Funct. 2010 Aug;215(2):97-104
pubmed: 20938680
ACS Chem Neurosci. 2013 Jun 19;4(6):940-51
pubmed: 23477444
Brain. 2000 Apr;123 ( Pt 4):733-45
pubmed: 10734005
Expert Opin Pharmacother. 2019 Feb;20(2):219-230
pubmed: 30411647
Br J Pharmacol. 2018 Feb;175(4):590-605
pubmed: 29130486
Behav Pharmacol. 2009 Feb;20(1):1-17
pubmed: 19179847
Expert Opin Ther Targets. 2015 Mar;19(3):377-98
pubmed: 25486101
Eur J Pharmacol. 1992 Dec 15;229(2-3):203-9
pubmed: 1362704
Behav Brain Res. 2018 Feb 26;339:11-18
pubmed: 29137945
Mol Neurobiol. 2018 Feb;55(2):1054-1067
pubmed: 28092083
Neurology. 2016 Jan 19;86(3):224-30
pubmed: 26718579
Proc Natl Acad Sci U S A. 1997 Apr 1;94(7):3363-7
pubmed: 9096399
Neurology. 2007 Apr 17;68(16):1262-7
pubmed: 17438216
Brain Res. 2012 Feb 9;1437:69-76
pubmed: 22227455
Neurosci Lett. 2009 Feb 6;450(3):332-5
pubmed: 19022350
J Neurosci. 1999 Jun 1;19(11):4627-33
pubmed: 10341260
Eur J Pharmacol. 1990 Jan 17;175(3):333-40
pubmed: 1969802
Parkinsonism Relat Disord. 2005 Jun;11 Suppl 1:S25-9
pubmed: 15885624
Eur J Pharmacol. 2003 Aug 8;474(2-3):223-6
pubmed: 12921866
Eur J Pharmacol. 2013 Nov 5;719(1-3):25-33
pubmed: 23872400
Neuropharmacology. 2016 Jan;100:106-15
pubmed: 25896768
J Neurosci. 2006 Jul 5;26(27):7272-80
pubmed: 16822985
Curr Opin Neurol. 2015 Aug;28(4):375-81
pubmed: 26110807
Bioorg Med Chem. 2014 Jun 15;22(12):3105-14
pubmed: 24800940
Nat Med. 2003 Jun;9(6):762-7
pubmed: 12740572
Sci Rep. 2017 Nov 28;7(1):16533
pubmed: 29184069
Neuroreport. 2013 Jul 10;24(10):509-14
pubmed: 23636255
J Pharmacol Exp Ther. 2000 Dec;295(3):1223-31
pubmed: 11082459
Physiol Rev. 1998 Jan;78(1):189-225
pubmed: 9457173
J Neurosci. 2003 Sep 17;23(24):8506-12
pubmed: 13679419
Int J Neurosci. 2015;125(10):717-25
pubmed: 25364880
Neurobiol Dis. 2019 Sep;129:1-12
pubmed: 31051233
Neurosci Lett. 2011 Nov 14;505(2):104-8
pubmed: 22001575
Parkinsonism Relat Disord. 2001 Jul;7(3):225-230
pubmed: 11331190
Transl Psychiatry. 2014 Jun 17;4:e401
pubmed: 24937095
PLoS One. 2013 Oct 18;8(10):e76595
pubmed: 24204641
Neuron. 2003 Sep 11;39(6):889-909
pubmed: 12971891
J Neural Transm (Vienna). 2018 Aug;125(8):1187-1194
pubmed: 29417335
Mol Pharmacol. 2013 Jun;83(6):1176-89
pubmed: 23543412
Neuropharmacology. 1996;35(11):1503-19
pubmed: 9025098
Ann N Y Acad Sci. 1999;890:7-25
pubmed: 10668410
Exp Neurol. 2008 Aug;212(2):522-31
pubmed: 18571649
Neurology. 2007 Nov 6;69(19):1836-42
pubmed: 17984451
Mol Neurobiol. 2017 Mar;54(2):1033-1045
pubmed: 26801190
CNS Drugs. 2010 Oct;24(10):829-41
pubmed: 20839895
Biochim Biophys Acta. 2009 Jul;1792(7):688-702
pubmed: 19007882
Neurosci Lett. 1996 Aug 23;214(2-3):75-8
pubmed: 8878087
J Neurosci Res. 2013 Oct;91(10):1371-81
pubmed: 23913715
Synapse. 2009 Sep;63(9):717-28
pubmed: 19425052
Neuroscience. 2010 Sep 15;169(4):1557-66
pubmed: 20600664
Pharmacol Ther. 2016 Sep;165:164-77
pubmed: 27343365
Brain Res Brain Res Rev. 2005 Jul;49(1):77-105
pubmed: 15960988
Arch Neurol. 2007 Aug;64(8):1089-96
pubmed: 17698698
Behav Brain Res. 2014 Apr 15;263:46-50
pubmed: 24462727
Neurochem Res. 2010 Oct;35(10):1546-56
pubmed: 20635141
J Korean Med Sci. 2018 Nov 01;33(47):e300
pubmed: 30450025
Front Pharmacol. 2017 Oct 04;8:710
pubmed: 29046641
Neuropharmacology. 2000 Feb 14;39(4):586-98
pubmed: 10728880
J Neurosci Res. 2002 Jun 15;68(6):716-29
pubmed: 12111832
Brain Struct Funct. 2009 Sep;213(4-5):375-93
pubmed: 19669160
Neuropharmacology. 2010 Feb;58(2):528-36
pubmed: 19733554
Brain Res. 1999 Aug 14;838(1-2):51-9
pubmed: 10446316
Neuroreport. 1997 Nov 10;8(16):3553-8
pubmed: 9427325
J Pharmacol Exp Ther. 2008 Feb;324(2):600-11
pubmed: 18024787
Neuropharmacology. 1999 Apr;38(4):555-65
pubmed: 10221759
Neurobiol Dis. 2019 Jan;121:120-130
pubmed: 30261284
Behav Pharmacol. 1998 Sep;9(5-6):445-55
pubmed: 9832930
Arch Neurol. 2010 May;67(5):589-95
pubmed: 20457959
Psychopharmacology (Berl). 2000 Jul;151(1):91-7
pubmed: 10958122
J Pharmacol Exp Ther. 2004 Nov;311(2):770-7
pubmed: 15226382
Sci Rep. 2017 Mar 14;7:44426
pubmed: 28290500
JAMA Intern Med. 2014 Dec;174(12):1930-3
pubmed: 25329919
Br J Pharmacol. 2015 Feb;172(4):1124-35
pubmed: 25339241
J Neurol Neurosurg Psychiatry. 2014 Aug;85(8):840-4
pubmed: 24434037
Neuropsychopharmacology. 2003 Jan;28(1):108-18
pubmed: 12496946
BMC Pharmacol. 2010 Feb 05;10:2
pubmed: 20137065
Parkinsonism Relat Disord. 2012 Jun;18(5):488-93
pubmed: 22326237
Eur J Pharmacol. 1997 Nov 27;339(2-3):261-70
pubmed: 9473144