A titanic drug resistance threat in Cryptococcus neoformans.
Journal
Current opinion in microbiology
ISSN: 1879-0364
Titre abrégé: Curr Opin Microbiol
Pays: England
ID NLM: 9815056
Informations de publication
Date de publication:
12 2019
12 2019
Historique:
received:
12
04
2019
revised:
01
10
2019
accepted:
01
11
2019
pubmed:
26
11
2019
medline:
12
8
2020
entrez:
26
11
2019
Statut:
ppublish
Résumé
Increasing resistance to frontline antifungals is a growing threat to global health. In the face of high rates of relapse for patients with cryptococcal meningitis and frequent drug resistance in clinical isolates, recent insights into Cryptococcus neoformans morphogenesis and genome plasticity take on new and urgent meaning. Here we review the state of the understanding of mechanisms of drug resistance in the context of host-relevant changes in Cryptococcus morphology and cell ploidy.
Identifiants
pubmed: 31765991
pii: S1369-5274(18)30109-7
doi: 10.1016/j.mib.2019.11.001
pmc: PMC6941473
mid: NIHMS1542065
pii:
doi:
Substances chimiques
Antifungal Agents
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
158-164Subventions
Organisme : NIAID NIH HHS
ID : R01 AI134636
Pays : United States
Organisme : Wellcome Trust
ID : 211241/Z/18/Z
Pays : United Kingdom
Organisme : National Centre for the Replacement, Refinement and Reduction of Animals in Research
ID : NC/R001472/1
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : NIGMS NIH HHS
ID : K12 GM119955
Pays : United States
Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.
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