Kinetic Modelling of [
Animals
Biomarkers
Gallium Radioisotopes
Kinetics
Molecular Imaging
Osteomyelitis
/ veterinary
Positron Emission Tomography Computed Tomography
Positron-Emission Tomography
Radioactive Tracers
Sialic Acid Binding Immunoglobulin-like Lectins
Soft Tissue Infections
/ veterinary
Swine
Swine Diseases
/ diagnosis
Siglec-9
Staphylococcus aureus
VAP-1
animal model
gallium-68
infection
inflammation
kinetic analysis
osteomyelitis
vascular adhesion protein
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
13 Nov 2019
13 Nov 2019
Historique:
received:
02
10
2019
revised:
07
11
2019
accepted:
10
11
2019
entrez:
27
11
2019
pubmed:
27
11
2019
medline:
21
4
2020
Statut:
epublish
Résumé
[ Eight pigs with osteomyelitis and soft tissue infections in the right hind limb were dynamically PET scanned for 60 min along with arterial blood sampling. The fraction of radioactivity in the blood accounted for by the parent tracer was evaluated with radio-high-performance liquid chromatography. One- and two-tissue compartment models were used for pharmacokinetic evaluation. Post-mortem soft tissue samples from one pig were analysed with anti-VAP-1 immunofluorescence. In each analysis, the animal's non-infected left hind limb was used as a control. Tracer uptake was elevated in soft tissue infections but remained low in osteomyelitis. The kinetics of [ The kinetics of [
Sections du résumé
BACKGROUND
BACKGROUND
[
METHODS
METHODS
Eight pigs with osteomyelitis and soft tissue infections in the right hind limb were dynamically PET scanned for 60 min along with arterial blood sampling. The fraction of radioactivity in the blood accounted for by the parent tracer was evaluated with radio-high-performance liquid chromatography. One- and two-tissue compartment models were used for pharmacokinetic evaluation. Post-mortem soft tissue samples from one pig were analysed with anti-VAP-1 immunofluorescence. In each analysis, the animal's non-infected left hind limb was used as a control.
RESULTS
RESULTS
Tracer uptake was elevated in soft tissue infections but remained low in osteomyelitis. The kinetics of [
CONCLUSION
CONCLUSIONS
The kinetics of [
Identifiants
pubmed: 31766140
pii: molecules24224094
doi: 10.3390/molecules24224094
pmc: PMC6891593
pii:
doi:
Substances chimiques
Biomarkers
0
Gallium Radioisotopes
0
Radioactive Tracers
0
Sialic Acid Binding Immunoglobulin-like Lectins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Teknologi og Produktion, Det Frie Forskningsråd
ID : 0602-01911B (11-107077)
Organisme : Jane ja Aatos Erkon Säätiö
ID : to AR
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