Experimental Cannabinoid 2 Receptor Activation by Phyto-Derived and Synthetic Cannabinoid Ligands in LPS-Induced Interstitial Cystitis in Mice.
Animals
Behavior, Animal
/ drug effects
Cannabinoids
/ pharmacology
Cystitis, Interstitial
/ chemically induced
Disease Models, Animal
Female
Hyperalgesia
/ drug therapy
Inflammation
/ drug therapy
Lipopolysaccharides
/ toxicity
Mice
Mice, Inbred BALB C
Polycyclic Sesquiterpenes
/ pharmacology
Receptor, Cannabinoid, CB2
/ metabolism
allodynia
cannabinoid receptors
endocannabinoid system
inflammation
interstitial cystitis
microcirculation
sesquiterpenoid
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
21 Nov 2019
21 Nov 2019
Historique:
received:
24
10
2019
revised:
14
11
2019
accepted:
19
11
2019
entrez:
27
11
2019
pubmed:
27
11
2019
medline:
14
5
2020
Statut:
epublish
Résumé
Interstitial cystitis (IC) is a chronic bladder disorder with unclear etiology. The endocannabinoid system has been identified as a key regulator of immune function, with experimental evidence for the involvement of cannabinoid receptors in bladder inflammation. This study used intravital microscopy (IVM) and behavioral testing in lipopolysaccharide-induced IC, to investigate the anti-inflammatory analgesic effects of a natural dietary sesquiterpenoid, beta-caryophyllene (BCP), which is present in cannabis among other plants, and has reported agonist actions at the cannabinoid 2 receptor (CB
Identifiants
pubmed: 31766439
pii: molecules24234239
doi: 10.3390/molecules24234239
pmc: PMC6930590
pii:
doi:
Substances chimiques
Cannabinoids
0
Lipopolysaccharides
0
Polycyclic Sesquiterpenes
0
Receptor, Cannabinoid, CB2
0
caryophyllene
BHW853AU9H
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
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