Astaxanthin Inhibits Mitochondrial Permeability Transition Pore Opening in Rat Heart Mitochondria.

astaxantin (AST) administration cell signaling mitochondria non-specific pore permeability transition regulatory proteins of mPTP

Journal

Antioxidants (Basel, Switzerland)
ISSN: 2076-3921
Titre abrégé: Antioxidants (Basel)
Pays: Switzerland
ID NLM: 101668981

Informations de publication

Date de publication:
21 Nov 2019
Historique:
received: 22 10 2019
revised: 19 11 2019
accepted: 20 11 2019
entrez: 27 11 2019
pubmed: 27 11 2019
medline: 27 11 2019
Statut: epublish

Résumé

The mitochondrion is the main organelle of oxidative stress in cells. Increased permeability of the inner mitochondrial membrane is a key phenomenon in cell death. Changes in membrane permeability result from the opening of the mitochondrial permeability transition pore (mPTP), a large-conductance channel that forms after the overload of mitochondria with Ca

Identifiants

pubmed: 31766490
pii: antiox8120576
doi: 10.3390/antiox8120576
pmc: PMC6943429
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : Российский Фонд Фундаментальных Исследований (РФФИ)
ID : 17-04-00747

Déclaration de conflit d'intérêts

The authors declare no conflict of interest.

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Auteurs

Yulia Baburina (Y)

Laboratory of Pharmacological Regulation of Cell Resistance, Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region 142290, Russia.

Roman Krestinin (R)

Laboratory of Pharmacological Regulation of Cell Resistance, Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region 142290, Russia.
Department of Biophysics and Medicobiological Sciences, Pushchino State Natural Science Institute, Moscow Region, Pushchino 142290, Russia.

Irina Odinokova (I)

Laboratory of Pharmacological Regulation of Cell Resistance, Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region 142290, Russia.

Linda Sotnikova (L)

Laboratory of Pharmacological Regulation of Cell Resistance, Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region 142290, Russia.

Alexey Kruglov (A)

Laboratory of Pharmacological Regulation of Cell Resistance, Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region 142290, Russia.

Olga Krestinina (O)

Laboratory of Pharmacological Regulation of Cell Resistance, Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region 142290, Russia.
Department of Biophysics and Medicobiological Sciences, Pushchino State Natural Science Institute, Moscow Region, Pushchino 142290, Russia.

Classifications MeSH