Vitamin D Deficiency and Sarcopenia in Older Persons.
Vitamin D
aging
malnutrition
nutritional intervention
physical frailty
sarcopenia
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
21 Nov 2019
21 Nov 2019
Historique:
received:
05
11
2019
accepted:
18
11
2019
entrez:
27
11
2019
pubmed:
27
11
2019
medline:
30
5
2020
Statut:
epublish
Résumé
Vitamin D deficiency is a common health problem worldwide, in particular among older people. Vitamin D regulates and modulates the physiology and function of multiple human systems, including the skeletal muscle. The effect of vitamin D on the muscle has been widely investigated, suggesting that this hormone can stimulate the proliferation and differentiation of skeletal muscle fibers, maintaining and improving muscle strength and physical performance. Older persons have a higher prevalence of low Vitamin D levels as a consequence of low dietary intake and reduced ultraviolet irradiation of the skin. Therefore, older people with vitamin D deficiency might be at risk of sarcopenia, a geriatric syndrome characterized by the progressive loss of skeletal muscle mass and strength often complicated by adverse events, such as falls, disability hospitalization and death. Several randomized clinical trials have been conducted to investigate the effect of oral vitamin D supplementation in older patients to prevent or treat sarcopenia, but results are still controversial. In this narrative review we summarize the biological, clinical and epidemiological evidence supporting the hypothesis of a causal association between Vitamin D deficiency and an increased risk of sarcopenia in older people.
Identifiants
pubmed: 31766576
pii: nu11122861
doi: 10.3390/nu11122861
pmc: PMC6950416
pii:
doi:
Substances chimiques
Vitamin D
1406-16-2
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Univeristà di Ferrara
ID : Bando FAR 2018
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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