Mechanistic Signatures of Human Papillomavirus Insertions in Anal Squamous Cell Carcinomas.
HPV
NFIX
anal cancer
integration
prognostic factor
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
22 Nov 2019
22 Nov 2019
Historique:
received:
21
10
2019
revised:
15
11
2019
accepted:
19
11
2019
entrez:
27
11
2019
pubmed:
27
11
2019
medline:
27
11
2019
Statut:
epublish
Résumé
The role of human papillomavirus (HPV) in anal squamous cell carcinoma (ASCC) carcinogenesis has been clearly established, involving the expression of viral oncoproteins and optional viral DNA integration into the host genome. In this article, we describe the various mechanisms and sites of HPV DNA insertion and assess their prognostic and predictive value in a large series of patients with HPV-positive ASCC with long-term follow-up. We retrospectively analyzed 96 tumor samples from 93 HPV-positive ASCC patients using the Capture-HPV method followed by Next-Generation Sequencing, allowing determination of HPV genotype and identification of the mechanisms and sites of viral genome integration. We identified five different mechanistic signatures of HPV insertions. The distribution of HPV signatures differed from that previously described in HPV-positive cervical carcinoma (
Identifiants
pubmed: 31766658
pii: cancers11121846
doi: 10.3390/cancers11121846
pmc: PMC6966520
pii:
doi:
Types de publication
Journal Article
Langues
eng
Références
Mutat Res Rev Mutat Res. 2017 Apr - Jun;772:3-12
pubmed: 28528688
Dig Liver Dis. 2012 Oct;44(10):803-11
pubmed: 22658644
Ann Oncol. 2014 Sep;25 Suppl 3:iii10-20
pubmed: 25001200
J Natl Cancer Inst. 2013 Feb 6;105(3):175-201
pubmed: 23297039
CA Cancer J Clin. 2019 Jan;69(1):7-34
pubmed: 30620402
J Clin Oncol. 1998 Aug;16(8):2613-9
pubmed: 9704710
FASEB J. 2001 Jun;15(8):1445-7
pubmed: 11387252
Hum Pathol. 2013 Jun;44(6):992-1002
pubmed: 23266444
Cancer Lett. 2017 Dec 1;410:124-138
pubmed: 28962832
Curr Mol Med. 2016;16(1):70-82
pubmed: 26695693
Radiother Oncol. 2014 Dec;113(3):331-6
pubmed: 25465729
NPJ Genom Med. 2016 Mar 16;1:16004
pubmed: 29263809
J Clin Oncol. 2009 Oct 20;27(30):5088-93
pubmed: 19770372
J Clin Oncol. 2014 Jun 10;32(17):1812-7
pubmed: 24821878
Vaccine. 2012 Nov 20;30 Suppl 5:F12-23
pubmed: 23199955
J Gynecol Oncol. 2015 Apr;26(2):111-7
pubmed: 25872892
Int J Cancer. 2015 Jan 1;136(1):98-107
pubmed: 24817381
Cell Rep. 2014 Jun 26;7(6):1833-41
pubmed: 24910434
Genes Chromosomes Cancer. 2018 Dec;57(12):638-644
pubmed: 30264502
Chin J Cancer Res. 2019 Apr;31(2):389-399
pubmed: 31156309
Br J Cancer. 2016 Jun 14;114(12):1387-94
pubmed: 27219019
Cancer Biomark. 2017 Sep 7;20(3):325-331
pubmed: 28800311
J Clin Oncol. 2013 Apr 20;31(12):1569-75
pubmed: 23509304
Head Neck. 2014 May;36(5):750-9
pubmed: 23606404
Clin Cancer Res. 2016 Sep 15;22(18):4735-45
pubmed: 27091409
Cancer Res. 1989 Sep 1;49(17):4677-81
pubmed: 2547512
Br J Cancer. 2015 Apr 14;112(8):1358-66
pubmed: 25871546
Oncogene. 2003 Jun 19;22(25):3977-84
pubmed: 12813471
Front Pharmacol. 2017 Aug 21;8:540
pubmed: 28871224
Nat Commun. 2016 Jul 13;7:12222
pubmed: 27406316
Radiology. 1982 Apr;143(1):29-36
pubmed: 7063747
Proc Natl Acad Sci U S A. 2014 Oct 28;111(43):15544-9
pubmed: 25313082
PLoS One. 2014 Feb 24;9(2):e88718
pubmed: 24586376
Cancer Epidemiol. 2013 Dec;37(6):807-12
pubmed: 24139594