A reduced form of nicotinamide riboside defines a new path for NAD
Metabolism
NAD(+)
Nicotinamide riboside
Journal
Molecular metabolism
ISSN: 2212-8778
Titre abrégé: Mol Metab
Pays: Germany
ID NLM: 101605730
Informations de publication
Date de publication:
12 2019
12 2019
Historique:
received:
05
06
2019
revised:
13
09
2019
accepted:
28
09
2019
entrez:
27
11
2019
pubmed:
27
11
2019
medline:
24
6
2020
Statut:
ppublish
Résumé
A decay in intracellular NAD Through a combination of metabolomics and pharmacological approaches, we describe how NRH, a reduced form of NR, serves as a potent NAD NRH acts as a more potent and faster NAD Our data identify a new pathway for NAD
Identifiants
pubmed: 31767171
pii: S2212-8778(19)30916-0
doi: 10.1016/j.molmet.2019.09.013
pmc: PMC6807296
pii:
doi:
Substances chimiques
Pyridinium Compounds
0
nicotinamide-beta-riboside
0I8H2M0L7N
NAD
0U46U6E8UK
Niacinamide
25X51I8RD4
Phosphotransferases (Alcohol Group Acceptor)
EC 2.7.1.-
nicotinamide riboside kinase
EC 2.7.1.-
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
192-202Subventions
Organisme : NCCIH NIH HHS
ID : R21 AT009908
Pays : United States
Informations de copyright
Copyright © 2019 The Author(s). Published by Elsevier GmbH.. All rights reserved.
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