Vitamin and cofactor acquisition in apicomplexans: Synthesis
Apicomplexa
Cryptosporidium
Plasmodium
Toxoplasma gondii
cofactor
metabolic pathway
metabolomics
nutrient acquisition
parasite metabolism
parasitology
vitamin
Journal
The Journal of biological chemistry
ISSN: 1083-351X
Titre abrégé: J Biol Chem
Pays: United States
ID NLM: 2985121R
Informations de publication
Date de publication:
17 01 2020
17 01 2020
Historique:
pubmed:
27
11
2019
medline:
4
9
2020
entrez:
27
11
2019
Statut:
ppublish
Résumé
The Apicomplexa phylum comprises diverse parasitic organisms that have evolved from a free-living ancestor. These obligate intracellular parasites exhibit versatile metabolic capabilities reflecting their capacity to survive and grow in different hosts and varying niches. Determined by nutrient availability, they either use their biosynthesis machineries or largely depend on their host for metabolite acquisition. Because vitamins cannot be synthesized by the mammalian host, the enzymes required for their synthesis in apicomplexan parasites represent a large repertoire of potential therapeutic targets. Here, we review recent advances in metabolic reconstruction and functional studies coupled to metabolomics that unravel the interplay between biosynthesis and salvage of vitamins and cofactors in apicomplexans. A particular emphasis is placed on
Identifiants
pubmed: 31767680
pii: S0021-9258(17)49928-5
doi: 10.1074/jbc.AW119.008150
pmc: PMC6970920
doi:
Substances chimiques
Coenzymes
0
Vitamins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
701-714Commentaires et corrections
Type : ErratumIn
Informations de copyright
© 2020 Krishnan et al.
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