Genetic and shared couple environmental contributions to smoking and alcohol use in the UK population.
Journal
Molecular psychiatry
ISSN: 1476-5578
Titre abrégé: Mol Psychiatry
Pays: England
ID NLM: 9607835
Informations de publication
Date de publication:
08 2021
08 2021
Historique:
received:
20
02
2019
accepted:
13
11
2019
revised:
07
11
2019
pubmed:
27
11
2019
medline:
28
1
2022
entrez:
27
11
2019
Statut:
ppublish
Résumé
Alcohol use and smoking are leading causes of death and disability worldwide. Both genetic and environmental factors have been shown to influence individual differences in the use of these substances. In the present study we tested whether genetic factors, modelled alongside common family environment, explained phenotypic variance in alcohol use and smoking behaviour in the Generation Scotland (GS) family sample of up to 19,377 individuals. SNP and pedigree-associated effects combined explained between 18 and 41% of the variance in substance use. Shared couple effects explained a significant amount of variance across all substance use traits, particularly alcohol intake, for which 38% of the phenotypic variance was explained. We tested whether the within-couple substance use associations were due to assortative mating by testing the association between partner polygenic risk scores in 34,987 couple pairs from the UK Biobank (UKB). No significant association between partner polygenic risk scores were observed. Associations between an individual's alcohol PRS (b = 0.05, S.E. = 0.006, p < 2 × 10
Identifiants
pubmed: 31767999
doi: 10.1038/s41380-019-0607-x
pii: 10.1038/s41380-019-0607-x
pmc: PMC8550945
doi:
Substances chimiques
ADH1B protein, human
EC 1.1.1.1
Alcohol Dehydrogenase
EC 1.1.1.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
4344-4354Subventions
Organisme : Medical Research Council
ID : MC_PC_12028
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_17228
Pays : United Kingdom
Organisme : Chief Scientist Office
ID : CZD/16/6
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/S035818/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_17209
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/K026992/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_QA137853
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00007/10
Pays : United Kingdom
Organisme : Wellcome Trust (Wellcome)
ID : 104036/Z/14/Z
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 216767/Z/19/Z
Pays : United Kingdom
Informations de copyright
© 2019. The Author(s).
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