κ-Opioid Receptor Modulation of GABAergic Inputs onto Ventrolateral Periaqueductal Gray Dopamine Neurons.
Dopamine
Inhibition
Periaqueductal gray
κ-Opioid
Journal
Molecular neuropsychiatry
ISSN: 2296-9209
Titre abrégé: Mol Neuropsychiatry
Pays: Switzerland
ID NLM: 101649121
Informations de publication
Date de publication:
Oct 2019
Oct 2019
Historique:
received:
21
09
2018
accepted:
15
01
2019
entrez:
27
11
2019
pubmed:
27
11
2019
medline:
27
11
2019
Statut:
ppublish
Résumé
The κ-opioid receptor (KOR) system has been implicated in the regulation of many behaviors including pain. While there are numerous studies suggesting KOR regulation of pain being mediated spinally, there have been reports of pain-like behaviors regulated by central KOR signaling. In particular, oxytocin-induced analgesia appears to be mediated by KOR receptors within the ventrolateral periaqueductal gray (vlPAG). We recently found that activation of dopamine (DA) neurons within the vlPAG is antinociceptive. In this study, we sought to determine the impact of KOR signaling on -GABAergic inputs onto vlPAG DA neurons, and the mechanism through which KOR impacts these inputs. We found that activation of KOR reduced GABAergic transmission onto vlPAG DA neurons. In addition, our data suggest this effect is mediated presynaptically via the G protein βγ-subunit. They raise the possibility that KOR activation disinhibits -vlPAG DA neurons, which could lead to altered regulation of pain-related behaviors.
Identifiants
pubmed: 31768372
doi: 10.1159/000496974
pii: mnp-0005-0190
pmc: PMC6873078
doi:
Types de publication
Journal Article
Langues
eng
Pagination
190-199Subventions
Organisme : NIDDK NIH HHS
ID : P30 DK056350
Pays : United States
Informations de copyright
Copyright © 2019 by S. Karger AG, Basel.
Déclaration de conflit d'intérêts
The authors have no conflicts of interest to declare.
Références
Biol Psychiatry. 2012 Apr 15;71(8):725-32
pubmed: 22225848
Proc Natl Acad Sci U S A. 2006 Feb 21;103(8):2938-42
pubmed: 16477003
Trends Pharmacol Sci. 1990 Feb;11(2):70-6
pubmed: 2156363
J Neurosci. 2006 Mar 8;26(10):2788-97
pubmed: 16525058
Elife. 2017 Apr 12;6:
pubmed: 28402252
J Biol Chem. 2006 Jun 30;281(26):18081-9
pubmed: 16648139
Rev Neurosci. 1995 Jul-Sep;6(3):279-86
pubmed: 8717638
Nature. 1976 Jul 22;262(5566):313-4
pubmed: 183126
Cell. 2016 Feb 11;164(4):617-31
pubmed: 26871628
J Biol Chem. 2012 Dec 7;287(50):41595-607
pubmed: 23086943
Drug Alcohol Depend. 2012 Aug 1;124(3):223-8
pubmed: 22356890
Neuron. 2017 Jun 21;94(6):1205-1219.e8
pubmed: 28602690
J Neurosci. 2007 Oct 24;27(43):11614-23
pubmed: 17959804
Synapse. 2018 Sep;72(9):e22042
pubmed: 29935119
Neuropsychopharmacology. 2016 Jan;41(1):103-25
pubmed: 26096838
Eur J Neurosci. 2018 Jan;47(1):40-47
pubmed: 29131433
Science. 2001 Apr 13;292(5515):293-7
pubmed: 11303105
J Neurosci. 2011 Jan 5;31(1):273-80
pubmed: 21209212
J Neurosci. 2018 Jun 13;38(24):5567-5583
pubmed: 29844022
Neuropsychopharmacology. 2014 Oct;39(11):2633-45
pubmed: 24853772
Pharmacol Rev. 1996 Dec;48(4):567-92
pubmed: 8981566
Neuroreport. 1998 Jun 1;9(8):1777-81
pubmed: 9665599
Eur J Pharmacol. 2015 Apr 15;753:73-87
pubmed: 25583178
Neuron. 2007 Dec 6;56(5):880-92
pubmed: 18054863
Brain Res. 2002 Feb 15;927(2):204-7
pubmed: 11821014
J Neurosci. 2009 Jun 3;29(22):7349-58
pubmed: 19494156
Science. 1982 Jan 22;215(4531):413-5
pubmed: 6120570
J Neurophysiol. 2007 Jan;97(1):883-91
pubmed: 17122312
Cell Mol Life Sci. 2012 Mar;69(6):857-96
pubmed: 22002579
Science. 1993 Jul 9;261(5118):218-21
pubmed: 8327893