Platelet Acetyl-CoA Carboxylase Phosphorylation: A Risk Stratification Marker That Reveals Platelet-Lipid Interplay in Coronary Artery Disease Patients.
ACC, acetyl-CoA carboxylase
AMPK
AMPK, adenosine monophosphate–activated protein kinase
AU, arbitrary units
AoC, extra-coronary calcification score
CAC, coronary artery calcification
CAD, coronary artery disease
S-CAD, stable coronary artery disease
TG, triglyceride
acetyl-CoA carboxylase
coronary artery disease
lipidomics
oxLDL, oxidized low-density lipoprotein
phosphoACC, acetyl-CoA carboxylase phosphorylation on serine 79
platelet
Journal
JACC. Basic to translational science
ISSN: 2452-302X
Titre abrégé: JACC Basic Transl Sci
Pays: United States
ID NLM: 101677259
Informations de publication
Date de publication:
Sep 2019
Sep 2019
Historique:
received:
29
11
2018
revised:
26
04
2019
accepted:
27
04
2019
entrez:
27
11
2019
pubmed:
27
11
2019
medline:
27
11
2019
Statut:
epublish
Résumé
Adenosine monophosphate-activated protein kinase (AMPK) acetyl-CoA carboxylase (ACC) signaling is activated in platelets by atherogenic lipids, particularly by oxidized low-density lipoproteins, through a CD36-dependent pathway. More interestingly, increased platelet AMPK-induced ACC phosphorylation is associated with the severity of coronary artery calcification as well as acute coronary events in coronary artery disease patients. Therefore, AMPK-induced ACC phosphorylation is a potential marker for risk stratification in suspected coronary artery disease patients. The inhibition of ACC resulting from its phosphorylation impacts platelet lipid content by down-regulating triglycerides, which in turn may affect platelet function.
Identifiants
pubmed: 31768476
doi: 10.1016/j.jacbts.2019.04.005
pii: S2452-302X(19)30178-0
pmc: PMC6872775
doi:
Types de publication
Journal Article
Langues
eng
Pagination
596-610Informations de copyright
© 2019 The Authors.
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