Thirty Years of Cancer Nanomedicine: Success, Frustration, and Hope.
EPR effect
cancer nanomedicine
clinical translation
nanoparticles
nano–bio interactions
tumor microenvironment
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
25 Nov 2019
25 Nov 2019
Historique:
received:
31
10
2019
revised:
21
11
2019
accepted:
22
11
2019
entrez:
27
11
2019
pubmed:
27
11
2019
medline:
27
11
2019
Statut:
epublish
Résumé
Starting with the enhanced permeability and retention (EPR) effect discovery, nanomedicine has gained a crucial role in cancer treatment. The advances in the field have led to the approval of nanodrugs with improved safety profile and still inspire the ongoing investigations. However, several restrictions, such as high manufacturing costs, technical challenges, and effectiveness below expectations, raised skeptical opinions within the scientific community about the clinical relevance of nanomedicine. In this review, we aim to give an overall vision of the current hurdles encountered by nanotherapeutics along with their design, development, and translation, and we offer a prospective view on possible strategies to overcome such limitations.
Identifiants
pubmed: 31769416
pii: cancers11121855
doi: 10.3390/cancers11121855
pmc: PMC6966668
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Associazione Italiana per la Ricerca sul Cancro
ID : 21565-2018
Organisme : Ministero dell'Istruzione, dell'Università e della Ricerca
ID : PRIN 2017E3A2NR-2017
Organisme : Regione Lombardia
ID : Direzione Generale Ricerca, Innovazione, Università, Export e Internazionalizzazione
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