The innate immune perspective of autoimmune and autoinflammatory conditions.
IL-1
NK
autoinflammatory
innate immunity
macrophages
Journal
Rheumatology (Oxford, England)
ISSN: 1462-0332
Titre abrégé: Rheumatology (Oxford)
Pays: England
ID NLM: 100883501
Informations de publication
Date de publication:
01 11 2019
01 11 2019
Historique:
received:
11
03
2019
revised:
01
08
2019
accepted:
19
08
2019
entrez:
27
11
2019
pubmed:
27
11
2019
medline:
9
4
2020
Statut:
ppublish
Résumé
Innate immunity is one of two immune defence system arms. It is present at birth and does not require 'learning' through exposure to foreign organisms. It activates various mechanisms collectively to eliminate pathogens and hold an infection until the adaptive response are mounted. The innate immune system consists of four elements: the epithelial barrier, cells (e.g. macrophages, NK cells), plasma proteins (e.g. complement) and cytokines. These components act in concert to induce complex processes, as well as recruitment, activation and differentiation of adaptive responses. The innate response is more than just the 'first line of defence', as it essentially withholds the vast majority of any intruder, has a complex interplay with the adaptive arm and is crucial for survival of the host. Finally, yet importantly, a myriad of diseases has been linked with innate immune dysregulation. In this mini-review we will shed some light on these conditions, particularly regarding autoinflammatory ones.
Identifiants
pubmed: 31769855
pii: 5643737
doi: 10.1093/rheumatology/kez387
pmc: PMC6878844
doi:
Substances chimiques
Cytokines
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
vi1-vi8Informations de copyright
© The Author(s) 2019. Published by Oxford University Press on behalf of the British Society for Rheumatology.
Références
Nat Rev Immunol. 2006 Mar;6(3):173-82
pubmed: 16498448
Nat Rev Nephrol. 2017 Jun;13(6):359-367
pubmed: 28316335
Nat Med. 2003 Dec;9(12):1484-90
pubmed: 14625544
Clinicoecon Outcomes Res. 2019 Feb 05;11:117-128
pubmed: 30787625
Blood. 2011 Jul 7;118(1):9-18
pubmed: 21562044
Cell Mol Life Sci. 2003 Dec;60(12):2604-21
pubmed: 14685686
Clin Exp Immunol. 2019 Sep;197(3):352-360
pubmed: 31009059
J Exp Med. 2003 Nov 17;198(10):1527-37
pubmed: 14623908
Nature. 1998 Mar 19;392(6673):245-52
pubmed: 9521319
Mod Rheumatol. 2009;19(3):245-52
pubmed: 19283441
Blood. 2017 Jan 19;129(3):289-298
pubmed: 27799164
Lupus. 1993 Aug;2(4):227-31
pubmed: 8268970
J Allergy Clin Immunol. 2014 Jan;133(1):217-24.e1-3
pubmed: 23768573
J Exp Med. 2011 Nov 21;208(12):2489-96
pubmed: 22084406
Nat Rev Immunol. 2013 Feb;13(2):145-9
pubmed: 23348417
Methods Mol Biol. 2016;1417:1-43
pubmed: 27221479
Front Immunol. 2017 Sep 13;8:1124
pubmed: 28955340
Allergy. 2014 Jan;69(1):3-16
pubmed: 24417229
J Allergy Clin Immunol. 2016 Aug;138(2):350-358.e1
pubmed: 27497277
J Clin Invest. 2012 Nov;122(11):3965-76
pubmed: 23064362
Immunology. 2010 Dec;131(4):451-8
pubmed: 21039469
Curr Opin Immunol. 2016 Oct;42:1-8
pubmed: 27206013
Open Access Rheumatol. 2014 Mar 03;6:15-25
pubmed: 27790031
Immunol Rev. 2018 Jan;281(1):197-232
pubmed: 29248002
Immunol Rev. 2005 Apr;204:9-26
pubmed: 15790347
Autoimmunity. 2007 Dec;40(8):560-6
pubmed: 18075790
Joint Bone Spine. 2009 Oct;76(5):464-73
pubmed: 19773191
Cardiol Rev. 2014 Nov-Dec;22(6):263-7
pubmed: 25050975
J Immunol. 2019 Jun 1;202(11):3309-3317
pubmed: 31019061
J Allergy Clin Immunol. 2013 Sep;132(3):515-525
pubmed: 23993353
Br J Dermatol. 2015 Aug;173(2):448-56
pubmed: 25904179
Bull NYU Hosp Jt Dis. 2010;68(3):211-7
pubmed: 20969554
Pediatr Rheumatol Online J. 2016 Jun 04;14(1):35
pubmed: 27260006
Hematol Oncol Clin North Am. 2015 Oct;29(5):915-25
pubmed: 26461151
Crit Care Med. 1997 Jul;25(7):1115-24
pubmed: 9233735
Rev Med Suisse. 2017 Jan 11;13(544-545):105-109
pubmed: 28703549
Allergy Asthma Immunol Res. 2014 Jul;6(4):276-87
pubmed: 24991450
Redox Biol. 2015 Dec;6:135-156
pubmed: 26210446
Harefuah. 2017 Jun;156(6):385-389
pubmed: 28661105
Am J Kidney Dis. 2005 Feb;45(2):295-302
pubmed: 15685507
J Histochem Cytochem. 2014 Oct;62(10):698-738
pubmed: 25062998
Adolesc Health Med Ther. 2017 Nov 09;8:125-135
pubmed: 29184458
Nat Immunol. 2017 Jul 19;18(8):832-842
pubmed: 28722725
J Allergy Clin Immunol. 2012 May;129(5):1307-13
pubmed: 22336078
Allergol Int. 2018 Apr;67(2):191-194
pubmed: 28993062
Clin Dev Immunol. 2013;2013:985753
pubmed: 23533458
J Immunol Methods. 2011 Jan 5;363(2):187-97
pubmed: 20598709
J Immunol. 2011 Jul 1;187(1):538-52
pubmed: 21613614
Proc Natl Acad Sci U S A. 2006 Feb 14;103(7):2286-91
pubmed: 16461458
J Exp Med. 2003 Jul 21;198(2):235-47
pubmed: 12874257
Rheumatol Int. 2000;19(4):141-7
pubmed: 10836524
Annu Rev Immunol. 2004;22:431-56
pubmed: 15032584
Clin Rev Allergy Immunol. 2019 May 30;:null
pubmed: 31147820
Nat Rev Rheumatol. 2010 Jun;6(6):317-25
pubmed: 20458333
Cold Spring Harb Perspect Biol. 2013 Jan 01;5(1):a011247
pubmed: 23284045
Clin J Am Soc Nephrol. 2015 Jul 7;10(7):1274-81
pubmed: 25845377
Rheumatol Int. 2019 Jun;39(6):971-990
pubmed: 30799530
J Rheumatol. 1996 Jan;23(1):171-7
pubmed: 8838528
J Neuropathol Exp Neurol. 1997 Jun;56(6):627-40
pubmed: 9184654
J Immunol. 2006 Nov 15;177(10):7275-86
pubmed: 17082646
Lupus. 1997;6(9):708-12
pubmed: 9412985
J Investig Dermatol Symp Proc. 2007 May;12(1):22-5
pubmed: 17502865
Expert Rev Clin Pharmacol. 2017 Aug;10(8):855-864
pubmed: 28586272
Semin Arthritis Rheum. 2019 Dec;49(3):474-484
pubmed: 31208713
Trends Immunol. 2017 Apr;38(4):248-260
pubmed: 28214100
Curr Opin Rheumatol. 2013 Mar;25(2):248-53
pubmed: 23249830
Adv Exp Med Biol. 2017;1027:21-37
pubmed: 29063428
Surg Infect (Larchmt). 2018 Feb/Mar;19(2):107-116
pubmed: 29364781
Arthritis Res. 2002;4 Suppl 3:S127-32
pubmed: 12110131
J Autoimmun. 2017 Jun;80:28-38
pubmed: 28196704
Immunol Rev. 2018 Mar;282(1):265-275
pubmed: 29431217
Nat Rev Immunol. 2013 Aug;13(8):566-77
pubmed: 23827956
Blood. 2011 Apr 7;117(14):3720-32
pubmed: 21304099
Crit Care Med. 2016 Feb;44(2):275-81
pubmed: 26584195
Br J Dermatol. 2018 Sep;179(3):570-581
pubmed: 29761483
Nat Med. 2005 Mar;11(3):335-9
pubmed: 15735651
Drug Des Devel Ther. 2014 Mar 24;8:341-8
pubmed: 24711694
Nat Immunol. 2002 Feb;3(2):121-6
pubmed: 11812988
Presse Med. 2019 Feb;48(1 Pt 2):e61-e76
pubmed: 30686512
J Cutan Med Surg. 2017 May/Jun;21(3):227-236
pubmed: 28300440
Immunol Cell Biol. 1998 Feb;76(1):20-6
pubmed: 9553772
Scand J Rheumatol. 2019 May;48(3):235-238
pubmed: 30668200
Ann N Y Acad Sci. 2011 Nov;1238:91-8
pubmed: 22129056
Proc Natl Acad Sci U S A. 2014 Mar 4;111(9):3526-31
pubmed: 24550444
Ann Rheum Dis. 2012 Jan;71(1):120-8
pubmed: 21914629
J Immunol. 2006 Feb 15;176(4):2095-104
pubmed: 16455965
Am J Med. 2015 Sep;128(9):950-5
pubmed: 25837517
Dev Cell. 2003 Feb;4(2):146-8
pubmed: 12586056
Curr Mol Med. 2009 Apr;9(3):365-74
pubmed: 19355917
PLoS One. 2015 Mar 11;10(3):e0120411
pubmed: 25760949
Clin Rev Allergy Immunol. 2016 Dec;51(3):315-328
pubmed: 26385242
Immunity. 2007 May;26(5):629-41
pubmed: 17509906
Front Immunol. 2013 May 24;4:120
pubmed: 23745122
Eur J Pharmacol. 2016 May 5;778:84-9
pubmed: 25941086
Open Access Rheumatol. 2017 Mar 02;9:21-28
pubmed: 28280401
Adv Pharm Bull. 2015 Dec;5(Suppl 1):605-14
pubmed: 26793605
Gut. 1999 Aug;45(2):210-7
pubmed: 10403732
Immunotherapy. 2014;6(10):1127-43
pubmed: 25428650
Semin Arthritis Rheum. 2017 Oct;47(2):295-302
pubmed: 28757235
Nat Rev Rheumatol. 2011 Sep 27;7(12):691-9
pubmed: 21947176
J Lab Clin Med. 2006 May;147(5):242-9
pubmed: 16697772
Rheumatol Ther. 2017 Dec;4(2):375-389
pubmed: 28840531
Adv Clin Chem. 2016;77:1-75
pubmed: 27717414
N Engl J Med. 2000 Aug 3;343(5):338-44
pubmed: 10922424