The biology of the adenovirus E1B 55K protein.
DNA replication
E1B 55K
E1B 55kDa
adenovirus
cellular transformation
mRNA export
post-transcriptional processing
protein degradation
replication compartments
viral oncogene
Journal
FEBS letters
ISSN: 1873-3468
Titre abrégé: FEBS Lett
Pays: England
ID NLM: 0155157
Informations de publication
Date de publication:
12 2019
12 2019
Historique:
received:
07
10
2019
revised:
15
11
2019
accepted:
18
11
2019
pubmed:
27
11
2019
medline:
19
6
2020
entrez:
27
11
2019
Statut:
ppublish
Résumé
The adenovirus E1B 55K (E1B) protein plays major roles in productive adenoviral infection and cellular transformation. Interest in E1B increased because of the potential of adenoviruses as therapeutic vectors, and the E1B gene is commonly deleted from adenovirus vectors for anticancer therapy. E1B activities are spatiotemporally regulated through SUMOylation and phosphorylation, and through interactions with multiple partners that occur presumably at different intracellular sites and times postinfection. E1B is implicated in the formation of viral replication compartments and regulates viral genome replication and transcription, transcriptional repression, degradation of cellular proteins, and several intranuclear steps of viral late mRNA biogenesis. Here, we review advances in our understanding of E1B during productive adenovirus replication and discuss fundamental aspects that remain unresolved.
Identifiants
pubmed: 31769868
doi: 10.1002/1873-3468.13694
doi:
Substances chimiques
Adenovirus E1B Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
3504-3517Subventions
Organisme : Consejo Nacional de Ciencia y Tecnología
ID : A1-S8696
Pays : International
Organisme : Consejo Nacional de Ciencia y Tecnología
ID : C0013-00267746
Pays : International
Organisme : Consejo Nacional de Ciencia y Tecnología
ID : S0016-280365
Pays : International
Organisme : Alexander von Humboldt-Stiftung
Pays : International
Informations de copyright
© 2019 Federation of European Biochemical Societies.
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