Relationship of Corneal Hysteresis and Anterior Lamina Cribrosa Displacement in Glaucoma.
Journal
American journal of ophthalmology
ISSN: 1879-1891
Titre abrégé: Am J Ophthalmol
Pays: United States
ID NLM: 0370500
Informations de publication
Date de publication:
04 2020
04 2020
Historique:
received:
01
08
2019
revised:
12
11
2019
accepted:
14
11
2019
pubmed:
27
11
2019
medline:
10
5
2020
entrez:
27
11
2019
Statut:
ppublish
Résumé
To investigate the relationship between corneal hysteresis (CH) and anterior lamina cribrosa surface (ALCS) displacement over time in a cohort of patients with glaucoma. Prospective observational case series. In this study, 147 eyes from 96 glaucoma or glaucoma suspect patients were followed for a mean of 3.5 years and 7.9 visits. Baseline CH measurements were obtained using the Ocular Response Analyzer (ORA; Reichert Ophthalmic Instruments Inc, Depew, New York, USA). The mean anterior lamina cribrosa surface depth (ALCSD) and choroidal thickness were by automated segmentation of spectral-domain optical coherence tomography (SD-OCT) scans. The rate of change of ALCSD was calculated using linear mixed effects models. Relationship between baseline CH and follow-up ALCSD rate of change was adjusted for confounding factors, including age, intraocular pressure (IOP), and choroidal thickness. The mean baseline CH was 9.4 mm Hg (95% confidence interval [CI] 9.1-9.7). Overall, the ALCS was displaced posteriorly at a rate of 0.78 μm/y (95% CI -1.82, 0.26). Seventeen eyes (11.5%) showed a significant posterior displacement of ALCS, whereas 22 eyes (15.0%) showed a significant anterior displacement of ALCS. The choroidal thickness thinned at a rate of -1.09 μm/y during the follow-up (P = .001). Multivariable mixed modeling showed that choroidal thinning, lower IOP change, and lower corneal hysteresis were significantly associated with posterior ALCS displacement over time (P = .034, P = .037, and P = .048). Each 1 mm lower CH was associated with 0.66 μm/y posterior displacement of the ALCS. Lower corneal hysteresis was significantly associated with posterior displacement of the anterior lamina cribrosa over time. These data provide additional support for lower corneal hysteresis being a risk factor for glaucoma progression.
Identifiants
pubmed: 31770514
pii: S0002-9394(19)30573-2
doi: 10.1016/j.ajo.2019.11.017
pmc: PMC7113091
mid: NIHMS1545299
pii:
doi:
Types de publication
Journal Article
Observational Study
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
134-143Subventions
Organisme : NEI NIH HHS
ID : R01 EY011008
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY029058
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY027510
Pays : United States
Organisme : NEI NIH HHS
ID : U10 EY014267
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY026574
Pays : United States
Organisme : NEI NIH HHS
ID : P30 EY022589
Pays : United States
Organisme : NEI NIH HHS
ID : T32 EY026590
Pays : United States
Organisme : NEI NIH HHS
ID : R21 EY027945
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY019869
Pays : United States
Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.
Références
Invest Ophthalmol Vis Sci. 2016 Feb;57(2):675-82
pubmed: 26906156
Arch Ophthalmol. 1981 Apr;99(4):635-49
pubmed: 6164357
Ophthalmology. 2013 Mar;120(3):553-559
pubmed: 23218823
Graefes Arch Clin Exp Ophthalmol. 2018 Dec;256(12):2391-2398
pubmed: 30251201
Ophthalmology. 2015 Apr;122(4):721-9
pubmed: 25433610
Prog Retin Eye Res. 2005 Jan;24(1):39-73
pubmed: 15555526
Invest Ophthalmol Vis Sci. 2014 Mar 28;55(3):2004-9
pubmed: 24595390
Am J Ophthalmol. 2006 May;141(5):868-75
pubmed: 16527231
J Glaucoma. 2009 Apr-May;18(4):280-3
pubmed: 19365191
Clin Ophthalmol. 2018 Mar 15;12:481-492
pubmed: 29588569
Acta Ophthalmol Scand. 2003 Jun;81(3):286-93
pubmed: 12780410
Invest Ophthalmol Vis Sci. 2010 Dec;51(12):6514-8
pubmed: 20574009
Ophthalmology. 2013 Aug;120(8):1533-40
pubmed: 23642371
Ophthalmology. 2015 Jul;122(7):1317-29
pubmed: 25972259
Invest Ophthalmol Vis Sci. 2018 Nov 1;59(13):5355-5365
pubmed: 30398627
Ophthalmology. 2011 Jan;118(1):52-9
pubmed: 20656352
Clin Exp Ophthalmol. 2012 Sep-Oct;40(7):682-8
pubmed: 22429725
Acta Ophthalmol. 2010 Feb;88(1):116-9
pubmed: 19891669
Invest Ophthalmol Vis Sci. 2017 May 1;58(5):2566-2577
pubmed: 28494490
J Cataract Refract Surg. 2005 Jan;31(1):156-62
pubmed: 15721708
Invest Ophthalmol Vis Sci. 2014 Mar 13;55(3):1531-9
pubmed: 24474264
J Glaucoma. 2008 Jun-Jul;17(4):318-28
pubmed: 18552618
Invest Ophthalmol Vis Sci. 2018 May 1;59(6):2357-2370
pubmed: 29847642
Ophthalmology. 2017 Sep;124(9):1392-1402
pubmed: 28461018
Br J Ophthalmol. 2017 Mar;101(3):290-294
pubmed: 27474156
Optom Vis Sci. 2008 Jun;85(6):425-35
pubmed: 18521012
J Glaucoma. 2012 Apr-May;21(4):209-13
pubmed: 21654511
Ophthalmology. 2014 Dec;121(12):2362-70
pubmed: 25108319
Invest Ophthalmol Vis Sci. 2008 Aug;49(8):3262-8
pubmed: 18316697
Am J Ophthalmol. 2016 Jun;166:29-36
pubmed: 26949135
Am J Ophthalmol. 2018 Mar;187:148-152
pubmed: 29305310
Invest Ophthalmol Vis Sci. 2005 Nov;46(11):4189-99
pubmed: 16249498
Graefes Arch Clin Exp Ophthalmol. 2008 May;246(5):735-8
pubmed: 18193259
Ophthalmology. 2019 Jan;126(1):49-54
pubmed: 30114419
Am J Ophthalmol. 2018 Feb;186:89-95
pubmed: 29103960
Lancet. 2004 May 22;363(9422):1711-20
pubmed: 15158634
Invest Ophthalmol Vis Sci. 2016 Jun 1;57(7):3331-9
pubmed: 27367500
Invest Ophthalmol Vis Sci. 2016 Mar;57(3):1293-300
pubmed: 26998715
Invest Ophthalmol Vis Sci. 2010 Nov;51(11):5675-84
pubmed: 20538991
Invest Ophthalmol Vis Sci. 2011 Sep 09;52(10):7109-21
pubmed: 21715355
Invest Ophthalmol Vis Sci. 2017 Mar 1;58(3):1825-1833
pubmed: 28353690