Amyloid-β, Tau, and 18F-Fluorodeoxyglucose Positron Emission Tomography in Posttraumatic Stress Disorder.
Aged
Amyloid beta-Peptides
/ genetics
Apolipoproteins E
/ genetics
Brain
/ diagnostic imaging
Cognition
Cognitive Reserve
Educational Status
Fluorodeoxyglucose F18
Humans
Intelligence Tests
Magnetic Resonance Imaging
Male
Mental Status and Dementia Tests
Middle Aged
Positron-Emission Tomography
Radiopharmaceuticals
Stress Disorders, Post-Traumatic
/ diagnostic imaging
Veterans
Vietnam Conflict
tau Proteins
/ genetics
Alzheimer’s disease
amyloid
biomarkers
dementia
positron emission tomography
posttraumatic stress disorder
tau
Journal
Journal of Alzheimer's disease : JAD
ISSN: 1875-8908
Titre abrégé: J Alzheimers Dis
Pays: Netherlands
ID NLM: 9814863
Informations de publication
Date de publication:
2020
2020
Historique:
pubmed:
28
11
2019
medline:
20
4
2021
entrez:
28
11
2019
Statut:
ppublish
Résumé
Epidemiological studies suggest a relationship between posttraumatic stress disorder (PTSD) and dementia. This study assessed whether Alzheimer's disease (AD) imaging biomarkers were elevated in Vietnam veterans with PTSD. The study compared cognition, amyloid-β, tau, regional brain metabolism and volumes, and the effect of APOE in 83 veterans with and without PTSD defined by the Clinician-Administered PTSD Scale. The PTSD group had significantly lower education, predicted premorbid IQ, total intracranial volume, and Montreal Cognitive Assessment score compared with the controls. There was no difference between the two groups in the imaging or genetic biomarkers for AD. Our findings do not support an association between AD pathology and PTSD of up to 50 years duration. Measures to assess cognitive reserve, a factor that may delay the onset of dementia, were lower in the PTSD group compared with the controls and this may account for the previously observed higher incidence of dementia with PTSD.
Sections du résumé
BACKGROUND
Epidemiological studies suggest a relationship between posttraumatic stress disorder (PTSD) and dementia.
OBJECTIVE
This study assessed whether Alzheimer's disease (AD) imaging biomarkers were elevated in Vietnam veterans with PTSD.
METHODS
The study compared cognition, amyloid-β, tau, regional brain metabolism and volumes, and the effect of APOE in 83 veterans with and without PTSD defined by the Clinician-Administered PTSD Scale.
RESULTS
The PTSD group had significantly lower education, predicted premorbid IQ, total intracranial volume, and Montreal Cognitive Assessment score compared with the controls. There was no difference between the two groups in the imaging or genetic biomarkers for AD.
CONCLUSION
Our findings do not support an association between AD pathology and PTSD of up to 50 years duration. Measures to assess cognitive reserve, a factor that may delay the onset of dementia, were lower in the PTSD group compared with the controls and this may account for the previously observed higher incidence of dementia with PTSD.
Identifiants
pubmed: 31771068
pii: JAD190913
doi: 10.3233/JAD-190913
doi:
Substances chimiques
Amyloid beta-Peptides
0
Apolipoproteins E
0
MAPT protein, human
0
Radiopharmaceuticals
0
tau Proteins
0
Fluorodeoxyglucose F18
0Z5B2CJX4D
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
163-173Subventions
Organisme : CIHR
Pays : Canada