Tables of Toxicity of Botulinum and Tetanus Neurotoxins.
botulinum neurotoxin
botulism
lethal dose
tetanus
tetanus neurotoxin
toxicity
Journal
Toxins
ISSN: 2072-6651
Titre abrégé: Toxins (Basel)
Pays: Switzerland
ID NLM: 101530765
Informations de publication
Date de publication:
22 11 2019
22 11 2019
Historique:
received:
08
10
2019
revised:
18
11
2019
accepted:
19
11
2019
entrez:
28
11
2019
pubmed:
28
11
2019
medline:
18
11
2020
Statut:
epublish
Résumé
Tetanus and botulinum neurotoxins are the most poisonous substances known, so much so as to be considered for a possible terrorist use. At the same time, botulinum neurotoxin type A1 is successfully used to treat a variety of human syndromes characterized by hyperactive cholinergic nerve terminals. The extreme toxicity of these neurotoxins is due to their neurospecificity and to their metalloprotease activity, which results in the deadly paralysis of tetanus and botulism. Recently, many novel botulinum neurotoxins and some botulinum-like toxins have been discovered. This large number of toxins differs in terms of toxicity and biological activity, providing a potential goldmine for novel therapeutics and for new molecular tools to dissect vesicular trafficking, fusion, and exocytosis. The scattered data on toxicity present in the literature require a systematic organization to be usable by scientists and clinicians. We have assembled here the data available in the literature on the toxicity of these toxins in different animal species. The internal comparison of these data provides insights on the biological activity of these toxins.
Identifiants
pubmed: 31771110
pii: toxins11120686
doi: 10.3390/toxins11120686
pmc: PMC6950492
pii:
doi:
Substances chimiques
Neurotoxins
0
Tetanus Toxin
0
Botulinum Toxins
EC 3.4.24.69
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Déclaration de conflit d'intérêts
The authors declare no conflicts of interest.
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