Functional Impacts of the BRCA1-mTORC2 Interaction in Breast Cancer.

BRCA1 Protein / genetics Breast Neoplasms / genetics Cell Line, Tumor Cell Survival DNA Damage / genetics Fluorescent Antibody Technique Humans Intracellular Signaling Peptides and Proteins / genetics Mechanistic Target of Rapamycin Complex 2 / genetics Phosphorylation / genetics Signal Transduction / genetics Two-Hybrid System Techniques
BRCA1 BRCT domain DNA damage response PRR5 RICTOR SIN1 mTORC2 complex protein-protein interactions

Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
23 Nov 2019
Historique:
received: 28 10 2019
revised: 20 11 2019
accepted: 21 11 2019
entrez: 28 11 2019
pubmed: 28 11 2019
medline: 14 4 2020
Statut: epublish

Résumé

Deleterious mutations in Breast Cancer 1 (

Identifiants

DOI: 10.3390/ijms20235876 PMID: 31771139 PMC: PMC6928641
pubmed: 31771139
pii: ijms20235876
doi: 10.3390/ijms20235876
pmc: PMC6928641
pii:
doi:

Substances chimiques

BRCA1 Protein 0
Intracellular Signaling Peptides and Proteins 0
PRR5 protein, human 0
Mechanistic Target of Rapamycin Complex 2 EC 2.7.11.1

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NIH HHS
ID : P30CA036727
Pays : United States
Organisme : NIGMS NIH HHS
ID : P20 GM121316
Pays : United States
Organisme : NIH HHS
ID : T32CA009476
Pays : United States
Organisme : NCI NIH HHS
ID : R21 CA184996
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA036727
Pays : United States
Organisme : NIH HHS
ID : R21CA184996
Pays : United States
Organisme : NCI NIH HHS
ID : T32 CA009476
Pays : United States
Organisme : NIH HHS
ID : P20GM121316
Pays : United States

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Auteurs

Kimiko L Krieger (KL)

Eppley Institute for Research in Cancer and Allied Diseases, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE 68198, USA.
ORCID: 0000-0002-7432-2729

Wen-Feng Hu (WF)

Eppley Institute for Research in Cancer and Allied Diseases, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Department of Emergency Medicine, College of Medicine, University of Nebraska Medical Center, Omaha, NE 68198, USA.

Tyler Ripperger (T)

Eppley Institute for Research in Cancer and Allied Diseases, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Department of Immunobiology, College of Medicine, University of Arizona, Tucson, AZ 85724, USA.

Nicholas T Woods (NT)

Eppley Institute for Research in Cancer and Allied Diseases, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE 68198, USA.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Protéine BRCA1 › Functional Impacts of the BRCA1-mTORC2...
questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Maladies du sein › Tumeurs du sein › Functional Impacts of the BRCA1-mTORC2...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Functional Impacts of the BRCA1-mTORC2...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Survie cellulaire › Functional Impacts of the BRCA1-mTORC2...
questionsmedicales.fr › Phénomènes génétiques › Altération de l'ADN › Functional Impacts of the BRCA1-mTORC2...
questionsmedicales.fr › Techniques d'investigation › Techniques immunologiques › Technique d'immunofluorescence › Functional Impacts of the BRCA1-mTORC2...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Functional Impacts of the BRCA1-mTORC2...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Functional Impacts of the BRCA1-mTORC2...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › Sérine-thréonine kinases TOR › Complexe-2 cible mécanistique de la rapamycine › Functional Impacts of the BRCA1-mTORC2...
questionsmedicales.fr › Métabolisme › Phosphorylation › Functional Impacts of the BRCA1-mTORC2...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Functional Impacts of the BRCA1-mTORC2...
questionsmedicales.fr › Techniques d'investigation › Techniques de sonde moléculaire › Techniques de double hybride › Functional Impacts of the BRCA1-mTORC2...