Gene Expression Profiles Controlled by the Alternative Splicing Factor Nova2 in Endothelial Cells.
Nova2
alternative splicing
angiogenesis
post-transcriptional regulation
vascular development
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
23 11 2019
23 11 2019
Historique:
received:
24
09
2019
revised:
11
11
2019
accepted:
20
11
2019
entrez:
28
11
2019
pubmed:
28
11
2019
medline:
22
9
2020
Statut:
epublish
Résumé
Alternative splicing (AS) plays an important role in expanding the complexity of the human genome through the production of specialized proteins regulating organ development and physiological functions, as well as contributing to several pathological conditions. How AS programs impact on the signaling pathways controlling endothelial cell (EC) functions and vascular development is largely unknown. Here we identified, through RNA-seq, changes in mRNA steady-state levels in ECs caused by the neuro-oncological ventral antigen 2 (Nova2), a key AS regulator of the vascular morphogenesis. Bioinformatics analyses identified significant enrichment for genes regulated by peroxisome proliferator-activated receptor-gamma (Ppar-γ) and E2F1 transcription factors. We also showed that Nova2 in ECs controlled the AS profiles of
Identifiants
pubmed: 31771184
pii: cells8121498
doi: 10.3390/cells8121498
pmc: PMC6953062
pii:
doi:
Substances chimiques
NOVA2 protein, human
0
Nerve Tissue Proteins
0
Neuro-Oncological Ventral Antigen
0
RNA-Binding Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
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